The Study Of Acupuncture Adjust The RAAS Of Primary Hypertension Patients With Anxiety State

ObjectiveThrough the prospective, placebo-controlled, randomized single blind intervention trial, to evaluate the clinical efficacy of acupuncture in treating primary hypertension with anxiety, observed the activity change of the renin-angiotensin-aldosterone system before and after acupuncture, explore the mechanism of acupuncture treatment of hypertension with anxiety.MethodsIn a prospective, placebo-controlled, randomized single blind intervention trial, in Guangdong Province Hospital of Traditional Chinese Medical’s cardiovascular department,103patients of hypertension with anxiety status were involved, who were randomly divided into an acupuncture group, placebo needle group and drug group. Three groups were treated with calcium antagonists or alpha receptor blockers, avoiding the use of angiotensin converting enzyme inhibitors, angiotensin receptor blockers, beta blockers and diuretics.The acupuncture group were treated with needle acupuncture (double-Hegu, Taichong),3times/week, four weeks of a course of treatment. Placebo needle group were treated with comfort acupoint. Drug group were treated with paroxetine20mg qd for early morning.Before and after treatment, blood pressure, heart rate recording, changes of RAAS activity in four hypertensive examination evaluation were tested. Take the Hamilton Anxiety Scale (HAMA), Self-rating Anxiety Scale (SAS) to assess the anxiety state. Take the WHOQOL-BREF quality of life scale to assess the life quality.Results103patients were included from January2011to December2011, the Guangdong Provincial Hospital of cardiovascular inpatient with hypertension and anxiety state were randomly divided into three groups, the treatment group (n=35), placebo needle group for34, drug group34.1、Balanced comparison, three groups’s basic data of equilibrium were comparable.2、Systolic pressure, diastolic pressure and heart rate were significantly decreased before and after treatment.3、Hamilton Anxiety Scale (HAMA) score in the treatment group and the drug control group after treatment than before treatment were significantly decreased (P<0.001). Acupuncture group and drug group decreased more obviously, there was significant difference between groups.4、The three groups after treatment Self-rating Anxiety Scale (SAS) were lower significantly than that before treatment, P<0.001. Similar to the HAMA score, also shows that the fall in blood pressure on anxiety of patients with remission of beneficial. And acupuncture group and drug group decreased more obviously, there was significant difference between groups (P<0.001), illustrates the combined at the same time the use of acupuncture and medication for anxiety relief had more positive role.5、Before the treatment, each group in the quality of life (WHOQOL-BREF) score of each domain score no significant difference (P>0.05), after treatment, there were significant differences between the three groups in the total quality of life of subjective feeling, physical field, psychological field, social field score (P<0.001), and the acupuncture group and medicine group than the placebo needle group score higher, that buck and psychological state of using acupuncture or drugs to the patient’s quality of life, improve the help. Among them, the physiological domain score acupuncture group than in drug group was higher, reflecting the acupuncture treatment of anxiety at the same time, play a role in improving physiological function, so as to contribute to the overall improvement in the quality of life.6、Hypertension four examinations of the three groups of patients before and after treatment. The results show, the three groups after treatment than before treatment of renin activity decreased; acupuncture group after treatment with angiotensin I, aldosterone also decreased significantly; medicine group after treatment than before treatment of angiotensin I, aldosterone has declined, but did not decrease obviously; acupuncture placebo group after treatment blood vessel of angiotensin Ⅰ, aldosterone decreased no obvious.7、Hypertension four examinations of the three groups of patients before and after treatment. The results show, the three groups after treatment than before treatment of renin activity decreased; acupuncture group after treatment with angiotensin Ⅰ, aldosterone also decreased significantly; medicine group after treatment than before treatment of angiotensin Ⅰ, aldosterone has declined, but did not decrease obviously; acupuncture placebo group after treatment blood vessel of angiotensin Ⅰ, aldosterone decreased no obviousConclusionFour Guan point acupuncture is effective treatment for primary hypertension with anxiety. Acupuncture treatment at the same time, can effectively improve the hypertension patients with anxiety state anxiety, improve the quality of life, can reduce serum rennin-angiotensin-aldosterone in patients.