| Spinal cord injury is a serious central nervous system trauma, surgical treatmentand medication to ease the change of spinal cord injury in varying degrees, but theconsequences still inevitably result in a patient with paraplegia. Spinal cord injury isoften occured at the time of the accident, as a result of the primary mechanicaldamage and secondary injury, resulting organization part or all of the nerve cells, glialcells died, and nerve conduction in the tissue fibers broken. The demyelinatingresulting lack of function of the spinal cord. Due to the uniqueness of the neurons,neurons with non-renewable, and spinal cord injury after partial spinal cord tissuemicroenvironment change, thereby inhibiting axonal regeneration in spinal cord tissue,ultimately makes the spinal cord death loss of neuronal function, causedinconvenience and pain of life for patients and their families.Contain a variety of active ingredients, including a wealth of ginsenoside inginseng, a variety of amino acids, polysaccharides and volatile oil components, andhas an extensive role in the body’s central nervous system, cardiovascular system,immune system and urogenital system, can enhance the body The noxious stimuliresistance. The researchers found ginsenoside of triterpenoids ginseng efficacy study,ginsenoside has a good role in the repair of spinal cord injury.In recent years, with the development of the stem cell research, the researchersare trying to use of embryonic stem cells to repair damaged spinal cord tissue, and thisresearch are becoming a research focus. Stem cell transplantation in the treatment ofnerve regeneration portability, brought to light for the treatment of spinal cord injury.After the induction of nerve cells transplanted into the spinal cord, can promoteremyelination, prompting host neurons form synapses again. The study suggests thatthe new implantable nerve cells integrated into the host nerve cells, and thus the partial restoration of the ability of the spinal cord to transmit signals.As all we known, the stem cells are stem cells is a Class wholly competent cells,capable differentiation as a specific cell type, also refers to a class having aself-renewal and the ability to replicate, and having a variety of differentiationpotential of the cells, they can be under suitable conditions differentiation into aparticular type of cells, the applications that they can replace the loss of function, lossof the ability to repair cells, so as to achieve the efficacy of the repair tissue function.Our study found that, with the repair capacity of stem cells, including embryonicstem cells (ESC), bone marrow mesenchymal stem cells (MSC), neural stem cells(NSC). Stem cells for repair of the central nervous system of embryonic stem cellsand neural stem cells. Currently little data on personnel with fetal liver stem cells intoneural stem cells and then to complete the study of the nervous system repair. Atpresent, no specific sign of liver stem cells have not. The experimental separation ofMSCs expressed CD44, CD29, CD105, separation liver MSCs cells has lowimmunogenicity favor the allogeneic cell transplantation. Research, are likely to playa good stability, which is likely to become one of the important means used in theclinical treatment of spinal cord injury and other central nervous system damage.The present study demonstrated that liver MSCs have the potential todifferentiate into nerve cells. Typical nerve cell morphology induced cells, whileexpression of the related proteins of nerve cells. nestin and NSE in the cells afterinduction of expression, GFAP expression, confirmed liver MSCs can differentiateinto neuron-like cells, without having to differentiate into glial cells. Then use itsginsenoside treatment of spinal cord injury in rats, found that spinal cord injury cansignificantly improve symptoms, restore their motor function.The theory of the the subjects of Al1en the to build rat model of spinal cordinjury as a research model of spinal cord injury repair, at the same time prove fetalliver stem cells can be induced to differentiate into neuron-like cells, and further helpto the treatment of spinal cord injury ginsenoside aims to explore both importantreference can be provided jointly by reducing ROS levels in the spinal cord damaged tissue cells, promoting cell resistance to apoptosis, and to reduce the damage of thespinal cord injury, and promote functional recovery, clinical spinal cord injury repairhas important guiding significance, it is expected to become the new technologies fortissue engineering and cell transplantation in the treatment. |
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