Study On Dynamic Changes Of Serum S100B Protein Concentrations In Patients With Cerebral Infarction Post-ischemic Preconditioning

Purpose:To study dynamic changes of S100B protein serum concentrations in patients with acute cerebral infarction post-ischemic preconditioning, record scores of clinical neurologic impairment and daily living ability,cerebral infarct size and types classified according to OCSP, imaging changes, average blood pressure, temperature, consciousness, leukocyte count data in patients with acute cerebral infarction with and without post-ischemic preconditioning, evaluat to relationship of dynamic changes of serum S100B concentration and these parameters with and without ischemic preconditioning, expound to the dynamic changes of serum S100B concentration and effects on cerebral infarction in patients with cerebral infarction post-ischemia preconditioning.Methods:The levels of S100B concentrations were measureed using ELISA method in serum of26patients with cerebral infarction within one week before the typical transient cerebral ischemia attack in days1,3,5and10days after onset, compared with58patients with acute cerebral infarction matched age and sex without transient ischemic attack.All the cases underwent brain MRI, part of digital subtraction cerebral angiography, The neurological status was evaluated by the standard of clinical neural functional deficit degree score in patients with CI of two groups in admission. Functional outcome was measured with the activities of daily living (ADL) Barthel index score at discharge from the hospital. The size of infracted brain area was based on cranial MRI data. All patients were classified according to OCSP. On taking vein blood, we measured blood pressure, body temperature, consciousness, ocular movement, leukocyte count and blood sugar.Results:Elevated concentrations of S100B (>0.2ug/L) were observed respectively in13,20,12and8at days1,3,5and10after onset, while that of control grope were32,53,32and20patients with CI of58. Serum concentrations of protein S100B have positive association with the neural functional deficit degree in admission, and negative association with the activities of daily living score at discharge from the hospital. The larger CI, the higher the serum concentrations of S100B. Increased concentrations of serum S100B at day3after stroke onset were correlated with body temperature, consciousness, ocular movement, leukocyte count, and the size of CI, but not with average arterial pressure, and blood surge. Average serum S100B protein concentration of study group in the disease in1,3and5days less than the control group,there is no obvious difference in10day after illness, laminar necrosis was found in the study group patient imaging, cerebral angiography revealed infarction proximal vascular stenosis or blockage.Conclusion:Increased serum concentrations of S100B in patients with CI indicate severe cerebral cell injury, the serum S100B concentration reflects the infarction lesion extent and severity of illness in patients with cerebral infarction, as the TIA attack, imaging showed some cases laminar necrosis, infarction proximal vessels showed stenosis or occlusion, increased serum S100B protein concentrations in disease after1,3days and5days after the disease were less than without TIA clinical manifestations are relatively light, so that the serum S100B concentrations can assist judge in prodiagnosis and the severity of cerebral infarction, TIA before infarction episodes may have a protective effecton cerebral infarction.