Jiangsu Gaoyou Crowd Serum Triglyceride Levels, Metabolic Syndrome And Blood Vessel Function Correlation Research

Section1The association between brachial-ankle pulsewave velocity, circulating triglycerides level and APOA5-1131T>C polymorphisms in a Chinese population1.1Correlations of brachial-ankle pulse wave velocity andcirculating triglycerides in a Chinese populationElevated levels of circulating triglycerides and increased arterial stiffness areassociated with cardiovascular disease, and the brachial-ankle pulse wave velocity(baPWV) was well accepted as a non-invasive marker of arterial stiffness. This studywas to investigate the correlation between the baPWV and circulating triglycerides.4421subjects aged18-74years who were recruited from a Chinese population,standardized questionnaires were used to collect the subject’s medical informationand anthropometric measurements were measured, the baPWV and routinebiochemical measurements of serum including lipid profiles were performed. Thestudy results showed that baPWV was significantly associated with the levels ofcirculating triglycerides (r=0.18, P<0.001), the stepwise forward linear regressionanalyses suggested that the common logarithm of triglycerides was independentlyassociated with the baPWV (β=0.07, P<0.001) after adjusting for age, sex, body massindex, waist-to-hip ratio, systolic blood pressure, heart rate, antihypertensivetreatment, and diabetes mellitus. In conclusion, the baPWV has a positive correlationwith circulating triglycerides in a Chinese population, but if there is a casualrelationship between them cannot be determined. 1.2The-1131T>C polymorphism in the apolipoprotein A5gene is associated with elevated levels of circulatingtriglycerides in a Chinese populationAnimal and human studies support the role of apolipoprotein A5(APOA5) in serumlipids profiles metabolism, especially in circulating triglycerides. We investigated theassociation between circulating triglyceride levels and the APOA5-1131T>C singlenucleotide polymorphism by examining data from4421subjects aged18-74yearswho were recruited from a Chinese population. Standardized questionnaires wereused to collect the subject’s medical information and anthropometric measurementswere measured, and routine biochemical measurements of lipid profiles wereperformed. The APO-1131T>C genotype distribution was as follows:49.9%for theTT genotype; and9.0%for the CC genotype, and the rest41.2%for the TC genotype.The minor C allele frequency of APOA5-1131T>C was0.3. The-1131C allele wasassociated with a5%(95%CI3-8%) increase in circulating triglycerides (adjusted forage, sex, body mass index, systolic blood pressure, heart rate, waist-to-hip ratio,diabetes mellitus, and antihypertensive treatment). In conclusion, the-1131T>Cpolymorphisms of the APOA5gene are associated with circulating triglycerides in aChinese population. 1.3Evaluation of circulating triglyceride levels andbrachial-ankle pulse wave velocity in a Chinese populationusing a Mendelian randomization designObservational studies are the mostly widely used methods in epidemiology research,meantime this method has residual problems with confounding factors and reversescausality so that not be able to accurately determine the casual relationship betweenan exposure and disease. Mendelian randomization could greatly aid observationalepidemiology to avoid confounding and reverse causation by potentially allowing anunbiased estimate of the effects of gene products on disease outcomes. In thepreviously studies we demonstrated that brachial-ankle pulse wave velocity (baPWV)had a positive correlation with circulating triglycerides and also replicated theassociation between the apolipoprotein A-V (ApoA5)-1131T>C polymorphism andtriglyceride levels, here we used ApoA5genotype as an instrumental variable toinvestigate the causal relationship between baPWV and circulating triglycerides. Theresults suggested that triglyceride was significantly associated with baPWV (β=0.18,P<0.001), and ApoA5-1131C had allele specific changes in circulating triglycerides(P=0.003) and the IV based estimated baPWV, but not associated with observedbaPWV (P=0.75). Our data suggest that the association between circulatingtriglyceride levels and brachial-ankle pulse wave velocity observed in manyobservational studies reflects confounding and reverse causation, rather than a causaleffect. Section2Brachial-ankle pulse wave velocity in relation tothe metabolic syndrome in a Chinese populationThe purpose of the present study was to investigate the association betweenbrachial-ankle pulse wave velocity (baPWV) and metabolic syndrome (MS) in aChinese population. MS was defined according to the Adult Treatment Panel IIIcriteria.4445subjects aged18-74years were recruited to collect the medicalinformation and anthropometric measurements were measured, the baPWV androutine biochemical measurements of serum including lipid profiles were performed.The prevalence of MS was17.2%for men and25.6%for women respectively,baPWV showed a significant relationship with age, body mass index, waistcircumstance, waist-to-hip ratio, blood pressure, heart rate, fasting glucose, totalcholesterol, triglycerides and low-density lipoprotein cholesterol. In adjusted analysis,subjects with the metabolic syndrome had significantly higher baPWV compared tothose without. the linear regression analyses suggested that systolic blood pressure,diastolic blood pressure, serum glucose concentration, high-density lipoproteincholesterol, triglycerides were independently associated with baPWV. In conclusion,our findings indicate that the MS is strongly associated with the risk of increasedbaPWV in this Chinese population.