| Henoch-Schonlein purpura nephritis is an immune complex by the (IC)-mediated systemic small vessel vasculitis, the center of this disease syndrome are hematuria, proteinuria, rash, purpura, joint swelling, pain, or see edema and so on, belongs to Chinese medicine, "blood card (purpura, hematuria, blood in the stool)" category. The pathogenesis of wind, wet, hot toxic mixture of evil, network overflow injured blood, blood pulse overflow outside. As early as the Qing Dynasty, sent Febrile Diseases, founder of Ye Tianshi pointed out:"Blood on the fear of consumption of blood intothe movement of blood, straight to Liangxue casual blood," "service earlier an unaffected evil land" and the idea that in the disease process China should take the initiative to take measures to prevent changes in the first, control the development of illness. This study was the " Yang Yin Liang Xue Soup " Repair HSPN renal damagein animal model research, validation of experience mentor Professor Ma Jian, " YangYin Liang Xue Soup " treatment of allergic purpura nephritis immunity,pharmacodynamics mechanisms, their clinical application providing micro-experimental basis.Henoch-Schonlein purpura nephritis is a common vascular allergic diseases, because the body's allergic reaction to certain allergens occurred, leading to increased capillary fragility and permeability, blood extravasation, resulting in the skin, mucous membranes and some organ hemorrhage; can simultaneously associated with angioedema, urticaria and other allergic manifestations; vascular lesions Department has IgA and complement component deposition of the pathological basis of the clinical syndrome. More common in children, male to female ratio of 2:1, and kidney in Henoch-Schonlein purpura involving the very common, its severity is not consistent with the extra-renal manifestations. View of its clinical manifestations, about 30%～70% of patients with hematuria and (or) proteinuria. According to statistics, Henoch-Schonlein purpura nephritis in all glomerular diseases account for about 15%. The disease pathology is divided into VI type, light microscopy, renal biopsy was found similar to this disease and IgA nephropathy. The typical glomerular lesions and mesangial proliferative glomerulonephritis with varying degrees of crescent formation. Henoch-Schonlein purpura is mainly immunoglobulin A (IgA)-mediated allergic diseases, the immune control is the main pathological mechanisms, humoral immune abnormalities, IgA, particularly the role of attention. T-cell dysfunction and a variety of pro-inflammatory factor disorders, and its immune complex activation of complement play a role. HSPN there is immune dysfunction: Th2 type cell activation so that IgA, IgE levels increased, especially IgA, the formation of IgA immune complexes and disease, interleukin (IL) 4,6,8 and tumor necrosis factor-α(TNFα) as an important cytokines regulating cell-mediated immunity, in the HSP/HSPN play an important role in the pathogenesis. So for the immune regulation function of the drug is present and future efforts.Experimental research program to further in-depth study from revealing aspects of immune regulation medicine Febrile Diseases, "Yin cooling blood side" control sensitivity purpura nephritis (HSPN) mechanism. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) determination of plasma interleukin-1 (IL-1) and TNF-a activity; using immunofluorescence kidneys (IgA, IgG, IgM); by flow cytometry CD3+, CD4+, CD8+T cell subsets, by immunoassay, from the point of view of immune regulation, "nourishing yin and cooling blood side" Prescriptions for prevention and treatment of allergic purpura nephritis (HSPN) mechanism. Peripheral blood CD4+, CD4+/CD8+ significantly reduced, while CD8+increased significantly, indicating that abnormal T-cell subsets. CD4+ decrease, resulting in a variety of lymphokines and help B cells produce antibodies and complement other features such as reduced cell subsets; CD8+increase, inhibit the role of CD4+ and B cells enhanced affect cell immune response and antibody formation. Thereby reducing immune function, leading to recurrent infections and poor prognosis.From the experimental study in-depth study reveals aspects of immune regulation Febrile Diseases in traditional Chinese medicine, " YangYin Liang Xue Soup " control sensitivity purpura nephritis (HSPN) mechanism. Double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) determination of plasma interleukin-1 (IL-1) and TNF-a activity; using immunofluorescence kidneys (IgA, IgG, IgM); by flow cytometry CD3+, CD4+, CD8+ T cell subsets, by immunoassay, from the point of view of immune regulation, " YangYin Liang Xue Soup "Prescriptions for prevention and treatment of allergic purpura nephritis (HSPN) mechanism.This study by observing the " YangYin Liang Xue Soup "with hormone therapy Henoch-Schonlein purpura nephritis role, draw the following conclusions:1, " YangYin Liang Xue Soup "cooperate with the hormone on Henoch-Schonlein purpura nephritis significant therapeutic effects, its possible mechanisms:the promotion of Liver protein synthesis increase, thereby raising the level of serum albumin to reduce hematuria, proteinuria, indirectly, for protection of glomerular, tubular interstitial role. At the same time inhibit cholesterol synthesis, lower triglycerides and may improve renal microcirculation, reduce the degree of kidney disease.2, Yin Liangxue party may by adjusting the pituitary-adrenal system, so that lower cortisol levels return to normal, reducing the side effects of hormones, improve hormone effect.3, Yin cooling blood can only reduce the plasma IL-1 and TNF-a levels, adjust the CD3+, CD4+ and CD8+ T cell subsets and the percentage or ratio, indicating that the side Henoch-Schonlein purpura nephritis in rats immune features may have some regulatory role.
|
PDF Full Text Request