The Theories Research Of Nanometer-iron Particles Targeted By Rotate Magnetic Field In Blood Flow

Tumor targeted therapeutic is the hot and difficulty point in mordern scientific world. The carriers of medical include antibody carrier, conjugant and active amylase carrier teal. The theoretic model is based on biology characteristic. Each drug has specific target and effect in specific tumor tissue.With the development of modern science and technology, the scientific value of nano-technology and nano-materials is increasingly important. Its application prospect has been widely recognized. The application of nanotechnology in medicine, and it has created a new subject-medical nanotechnology. This paper discuss a novel, location of the tumor can be treated with drugs-preparation of magnetic nanoparticles radioactive nuclides, the pressure when nano-particles in the blood of human and the circumstances of conglomeration by the effect of external magnetic field.Preparation Methods:carbonyl method to make nanoiron is adopted. Paramagnetic iron nanoparticles nuclides are obtained by radiating nanoiron after pulsed neutron reactor. Results:The average size of radio nuclides—nanoiron is less than 100nm; it has super paramagnetic, radioactivity and better magnetic function and can be effectively in the target location.When in the external magnetic field, the nanoparticles do not only effect by three roles pressure of blood, but also the strength of the magnetic field which will be the key role when nano-particles gathered at the part of focus and decide the gathering condition of nanoparticles. By synthesizing the three magnetic vectors in blood, blood viscosity, gravity and magnetic field, analyzing the movement of nano-particles in the blood vessels and using the soft of MATHCAD and ANSYS, the simulation results can effectively prove the location of iron nanoparticles aggregation in the blood vessel which we need. Targeted therapy can achieve this purpose.In order to orientate the drug carrier to tumor focus, it need to form a strong magnetic field gradient and satisfies the condition of the nanometer-iron particles aggregation. In order to solve the problem this paper sets forth following study:(1) This paper introduces the principle in the electromagnetic field, analysis the feasibility of target therapeutic by magnetic field gradient, establish the theory of rotated 3D magnetic field for targeted therapeutic of tumor.(2) This paper calculates the magnetic field intensity and the variety in different conditions using the MathCAD soft, simulate the model of magnet field using the ANSYS soft.(3) The major forces of Nano-particles in blood (laminar flow conditions) are the dynamic of blood flow and viscous forces and their gravitational force. By analyzing the composition and nature of blood, blood viscosity and velocity of the blood vessels, several calculation methods and former are deduced above.(4) The parameters were calculated and the model was designed. Validate the result by experiment.The result is well both in simulation and theoretical equipment. Gain the data for the for industry production.