Analysis Of Clinical Data And Application Of Dermoscope To Evaluate Efficacy Of Zi-shen And Hua-ban Herbal Decoction On Female Chloasma

Objective:①The analysis of predisposing factor and entity of a crowd of symptoms in Traditional Chinese Medicine(TCM) of female chloasma from clinical data.②To evaluate the efficacy and safety of zi-shen and hua-ban herbal decoction for the treatment of patients with female chloasma by dermoscope.Methods:①The subject adopted clinical-answer-sheets to analysis the predisposing factors and entity of a crowd of symptoms in TCM of female chloasma patients;②Adopted the opening, random and parallel contrast methodology to observe the clinical effect and safety of the zi-shen and hua-ban herbal decoction. The pigmentation of skin lesions was measured by a dermoscope, namely MicroskinⅡmultifunction system with polarizing microscope and digital image.Forty patients of therapy group with chloasma took the zi-shen and hua-ban herbal decoction orally twice daily for 12 weeks. And sixty patients of contrast group took Vitamin C and Vitamin E orally,the dose was 200mg and 100rrig respectively, three times a day.Both groups were topically treated with Si-Bai-Qu-Ban ointment twice daily and twelve weeks were needed for a course.Results and Discussion:The clinical data from 130 female chloasma patients shows that the age of the episode is between twenty and fifty years old,especially the patients of thirty to fouty is at most, which reached 53.1%; The patients with skin lesions of butterfly distribution was 49,which reached 37.7%. Among them 63 patients have dry face skin,which reached 48.5%.Firstly,the results of predisposing factors shows that tension,stress,sleepless and morosity are relevant with the onsets of chloasma significantly,there are 88 patients with Psychic factors,which reached 66.7%;Secondly,the factor of cyesis and oral contraceptives are another important evoking agents. There are 111 patients with menoxenia,which reached 85.4%; There are 53 patients who have the diagnosis gynecological disease,including Phlegmasia, cancers,and so on, which reached 40.8%; There are 36 patients of oral contraceptives usually, induced abortion and cyesis,which reached 27.7%. Thirdly,the solarization is also relevant with the chloasma.There are 64 patients who are wordking in sunlight,the fierce lamplight or the computer radiations, which reached 49.2%. There are 39 patients with family history.The tendency to heredity is about 30.0%. There are 24 patients with the cosmetic history and cosmetics of poor quality, which reached 30.0%;Besides,the factors such as nevus, freckles and another face dermatogic diseases such as acne, dermatitis,eczema,urticaria,verruca plana,vitiligo and so on are correlation with the episode.According to dialectical in TCM, the entity of a crowd of symptoms in TCM of female chloasma patients shows that there are 82 patients with the Shen-xu-xue-yu symptoms which reached 63.1% and 71 patients with the Gan-yu-Qi-Zhi symptoms, which reached 54.6% and 29 patients with the Pi-xu-shi-yun symptoms, which reached 22.3%.Above them,more patients have the both shen-xu and gan-yu symptoms in TCM, the entity of the crowd of symptoms in TCM is mixed with weakness and enriched evils.There are 65 patients who had finished the trial and 5 patients who had been absent(<20%).The average effective rate of thirty-eight therapy patients with chloasma was 71.1% 12 weeks later,which is more effective than the contrast group (P<0.05),that the average effective rate of twenty-seven contrast patients was 37.0%. In both of the groups, the values of L*,a*, b* and ITA°(Individual topology angle) showed statistical differences (P<0.01) before and after treatment. However, the change of L*,a*, b* and ITA°in the therapy group showed more statistical differences (P<0.01) than in the contrast group. No adverse effect was found during the study.Conclusion:The zi-shen and hua-ban herbal decoction is effective and safe in chloasma. The herbal prescription was consist of dodder seed,rehmannia dride rhizome,angelica,zechwan lovge rhizome,thorowax root,peony root,Caltrop, safflower,tuckahoe,largehead atractylodes rhizome,cassia twig,and so on. It has the effect of invigorate-kindey, Liver and moving blood.It can reduce the amount of melanin in the lesions, yellow pigment and lipochrome, and relieve the extent of telangiectasis in pigmented areas.The dermoscope has the character of no wound, objectively,exactly without individual judgement difference by eye-observe in evaluating the clinical effect.It is worthing of spreading.