A Possible Approach To CAD Based On FMRI Study Of Brain Physiological Baseline

Functional magnetic resonance imaging (fMRI) refers to the detection of hemodynamic changes that can be regional changes of blood flow, volume or oxygenation associated with neural activity, using the technology of MRI. It broadens quite remarkably our understanding of how the human brain works, both in the normal and diseased states. The most popular technique utilizes blood oxygenation level dependent (BOLD) contrast, which is based on the different magnetic properties of oxygenated (diamagnetic) and deoxygenated (paramagnetic) blood. These magnetic susceptibility differences lead to small, but detectable changes in susceptibility-weighted MR image intensity.This dissertation explores a possible approach for computer aided diagnosis (CAD) based on BOLD fMRI. It is divided into two main parts. Partâ… covering the first three chapters, is a broad overviews of the background knowledge, which also serves to set the remainder of the dissertation in context. Chapter 1 introduces physical principles of nuclear magnetic resonance (NMR), followed in Chapter 2 by a discussion of physiological foundation of BOLD phenomenon. Chapter 3 is a brief introduction of data analysis based on statistical parametric mapping (SPM). This portion is also aimed at newcomers in Bio-X laboratory and I hope that it is a useful context to them.Partâ…¡includes four chapters, this part studies animal model and human anxiety disorder studies. In Chapter 4, we present a template image of rat brain based on the brains of 8 male sham operated Wistar rats by spatially normalizing images to the same stereotaxial space. This method can be extended to other animal brain fMRI studies or brain lesion studies. In Chapter 5, using region-of-interest (ROI) analysis, we attempt to relate neurophysiologic parametric with behavior changes of IP-treated and NS-treated rats. Its target is to obtain a statistical inference threshold possessing physiological meaning, which separates the IP-treated rats from vehicle control. In Chapter 6, based on the two forgoing studies, we explored the relationship between fMRI BOLD signal and AD-like tau hyperphorylation. This study demonstrates that a reduced resting oxygen-(ROXY)-dependent signal can be used for detection in the absence of structural change. Final, in Chapter 7, are explore the psychorpathology of anxiety disorder in order to obtain correlative brain foci and nervous network served for further studies. Studies of semi-quantitative fMRI image analysis are in progress.