The purpose, content and result lie in the following. Ancient doctors holded colorectal cancer pathogen mainly in diet, accommodation, Waixie, congenital, emotional factors, while using Buyi, Wenli, Liqi drugs, Qingre; promoting blood circulation, Shouse, diarrhea, hemostatic. Modern in Qi stagnation, blood stasis, hot, wet, Zhengqi weak, therefore Qingre; Buyi; promoting blood circulation, hemostatic, Liqi.Saponins inhibited proliferation of LoVo, and paralleled to concentration and time, 500μg/mL72h on LoVo inhibition rate of 81.52%. The apoptosis of the characteristics was seen. Each drug group could be seen the emergence of hypodiploid peak by flow cytometry. 24h, DNA ladder emergenceed, and Bax rised, while Bcl-2 inhibied significantly with a dose-dependent manner, saponin group Bcl-2/Bax decreased. Caspase-3 was significantly increased with the concentration.Saponins on the mouse tumor CT-26 was significant inhibition with a dose-effect relationship, the maximum dose's average tumor inhibition rate at 39.97%, the tumor-bearing mice thymus, spleen index increased, NK cell activity rised. Bax and Caspase-3 were significantly increased. Bcl-2/Bax ratio decreased significantly.Conclusion can be deduce. Prevention is more important; Biaoben into account; Key Tong, identified the Han and Wen; Attention to good use of Wenxia. Han Ji Zhi is one of the main pathogenesis of colorectal cancer patients.Saponins significantly inhibited the growth of LoVo cells, induced by Apoptosis with time, dose-dependent relationship, arrested cell cycle, and inhibited tumor growth. Saponins can reduce the LoVo cells Bcl-2 expression while increased Bax, Caspase-3 protein expression.That saponins inhibited CT-26 mouse tumor growth and induceed apoptosis of colon cancer in mice is related to the reduction of Bcl-2 expression, increase the expression of Bax.
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