| Objective1 To study the therapeutic effects of Xifeng Dingchan Pill(XDP) on Parkinson's disease (PD) using acknowledged reformative Webster rating scale and Chinese medicine criteria.2 To study the effects of XDP on the life quality of PD patients using MOS-SF36 evaluative scale.3 To study the poison-reducing effects of Chinese medicine by observing the effects on PD and its complications.MethodsThe clinical research was followed up in randomized,controlled and opened clinical trial. According to the diagnostic criteria,outpatients and inpatients of medium-term PD patients, from the First Hospital affiliated to Henan University of Traditional Chinese Medicine,have been observed and been randomly divided into treatment and control group at the ratio of 1:1.The treatment group(n=30) were given madopar and XDP,control group(n=30) were only given madopar.It was used to evaluate the Webster score,quantification scores of symptoms in TCM, grip weight index(GWI),quality of life and some other complication in order to study the therapeutic efficacy and poison-reducing effects of XDP and its preponderance on PD.Results1 Clinical curative effect of XDP on PDClinical treatment effect outcomes were assessed using reformative Webster rating scale. The total rate of effect in the treatment group was 76.67%,whereas it was 53.33%in the control group.The treatment group was better than the control group in total effect rate.2 Effect of XDP on TCM symptomsCompared with the control group,the score of TCM symptoms decreased(p＜0.01),but it deteriorated in the control group.The efficacy of the treatment group was superior to that of western medical treatment(p＜0.01).Sustaining therapy leads to greater effect.3 Effect of XDP on the reformative Webster rating scoreAccording to symptom estimation,Webster score of both the treatment group and the control group was significantly reduced compared with those prior to the treatment(p＜0.01), Webster score at different time points had a trend of durative decrease.The efficacy of the treatment group was superior to that of western medical treatment(p＜0.01).Compared with those prior to the treatment,tremor factor and rigidity factor were all improved significantly in the two groups(p＜0.01,p＜0.05),akinesia factor and gait factor were also improved in the treatment group(p＜0.001).There is little improvement in the control group in terms of akinesia factor and gait factor(p＞0.05).No obvious effect was observed in both groups on postural reflex impairment factor.4 Effect of XDP on Grip Weight Index(GWI)In terms of GWI,there was significant difference in the two groups compared with those prior to the treatment(p＜0.01).The efficacy of the treatment group was superior to that of the control group(p＜0.05).5 Effect of XDP on the life qualityThe general health status was improved in the treatment group(p＜0.01).The life quality of the patients has been greatly improved in the treatment group,better than that of patients in western medicine group(p＜0.05).6 Effect of XDP on the complicationsThe complications score of the treatment group decreased markedly(p＜0.01) compared with that prior to the treatment,whereas that of the western medicine group increased(p＜0.01).Conclusion1 XDP has obvious effects on reducing Webster score and improving clinical symptoms of PD.2 XDP has significant preponderance on relieving TCM symptoms of PD.Sustaining therapy leads to greater effect,which has some correlation with the multi-target,multi-level and multi-approach regulation based on syndrome differentiation and treatment of TCM.3 XDP can markedly improve the life quality of PD patients.4 XDP can significantly reduce complications of PD,which shows Chinese medicine can relieve the toxic or side effects of Western medicines,greatly increase medical compliance of the patients,and help slow down the progress of PD. |
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