Combined Study Of FMRI And DTI For Working Memory Of Children In Fronto-parietal Lobe

Partâ… Combined study of fMRI and DTI for working memory of normal children in fronto-parietal lobeObjective:To explore whether there is relation between brain activity of working memory and anisotropy of the fronto-parietal white matter in children by combining fMRI and DTI.Material and methods:Twelve healthy children aged 10-12 years were investigated. Brain activity of working memory was measured using the blood oxygen level-dependent (BOLD) contrast with functional magnetic resonance imaging(fMRI) during performance of paced visual serial addition test(PVSAT).The group studies were analyzed using SPM2. White matter was investigated using diffusion tensor imaging(DTI) and fractional anisotropy(FA) was calculated with the software of DTV-â…¡.The activity map were overlaid upon FA maps.The relation between BOLD response and FA values in frontoparietal lobe were statistically analyzed.Result:The fronto-parietal cortex is mainly region activated by a working memory task,including inferior parietal lobe bilaterally,the inferior frontal gyrus bilaterally,the left superior frontal gyrus,the left medial frontal gyrus and the anterior part of the cingulate gyrus.Overlay of fMRI maps upon FA maps revealed that activated voxels were almost exclusively in regions of low anisotropy.The correlation was found between FA values in fronto-parietal white matter and BOLD response in the dorsolateral prefrontal cortex(DLPFC).Conclusion:BOLD response occurs within the relatively isotropic cortical grey matter and correlated with the maturation of white matter.The combination of both techniques can help to demonstrate the relation working memory function and anatomic structure. Partâ…¡Combined study of fMRI and DTI for working memory of children and adults in fronto-parietal lobeObjective:To explore whether there is developmental differences between children and adults in brain activity of working memory and anisotropy of the fronto-parietal white matter by combining fMRI and DTI.Material and methods:Twelve healthy children aged 10-12 years and twelve healthy adults aged 21-24 years were investigated.Brain activity of working memory was measured using the blood oxygen level-dependent(BOLD) contrast with functional magnetic resonance imaging(fMRI) during performance of paced visual serial addition test(PVSAT). The group studies were analyzed using SPM2.White matter was investigated using diffusion tensor imaging(DTI) and fractional anisotropy(FA) was calculated with the software of DTV-â…¡.The activity map were overlaid upon FA maps.The relation between BOLD response and FA values in fronto-parietal lobe were statistically analyzed.Result:Children activeated more voxels than adults in parietal lobe bilaterally and less in frontal lobe bilaterally.The FA values in fronto-parietal white matter in adult were higher than these in children.The correlation was found between FA values in frontoparietal white matter and BOLD response in the dorsolateral prefrontal cortex(DLPFC) in children and no correlation in adult.Conclusion:BOLD response was correlated with the maturation of white matter.The combination of both techniques can help to demonstrate the relation working memory function and anatomic structure during development. Partâ…¢Combined study of fMRI and DTI for working memory of children with learning disorders in fronto-parietal lobeObj ective:To examine brain activity of working memory and anisotropy of the frontoparietal white matter in children with learning disorders(LD) by combining fMRI and DTI.Material and methods:Twelve children with LD aged 10-12 years and twelve matched children as normal control were investigated.Brain activity of working memory was measured using the blood oxygen level-dependent(BOLD) contrast with functional magnetic resonance imaging(fMRI) during performance of paced visual serial addition test(PVSAT).The group studies were analyzed using SPM2.White matter was investigated using diffusion tensor imaging(DTI) and fractional anisotropy(FA) was calculated with the software of DTV-â…¡.The activity map were overlaid upon FA maps.The relation between BOLD response and FA values in fronto-parietal lobe were statistically analyzed.Result:Children with LD showed weaker activation in almost the entire frontoparietal lobe than matched children..The FA values in fronto-parietal white matter in children with LD were lower.The correlation was found between FA values in frontoparietal white matter and BOLD response in the dorsolateral prefrontal cortex(DLPFC) both in two groups.Conclusion:The weaker BOLD response of children with LD was possibly associated with the lower maturation of white matter in fronto-parietal lobe.