| Objective: The mechanism of the damage of angle-closure glaucoma (ACG) and whether this damage is related to neurodegenerative or not was studied. Angle-closure glaucoma (ACG), ranked the world second largest blinded disease, is a kind disease which represented as special optic nerve damaged, atrophy and tunnel vision. Pathologic intraocular pressure (IOP) rise is a main risk factor. But Clinical result shows that some patients who have normal intraocular pressure also representative glaucoma optic atrophy and tunnel vision, and simply reducing IOP using drug or operation practice cannot control the process of pathological changes in glaucoma. It seems that the rise in IOP is not the only reason of the damage of retina and optic nerve of the glaucoma . It may relate to theβ-amyloid which led to the damage of central nervous system and the factors which impact its degradation and sediment. Find out some new proofs about glaucoma retina optic damage.Methods: The samples of glaucoma eyeball and aqueous humor were collected. Using some basic methods such as immunochemistry, radioimmunology to investigate the factors for retinal ganglion cells damage in angle-closure glaucoma (ACG) and to determine whether it is relevant toβ-amyloid, tau and presenilin protein or not , then presume that glaucoma optic damage is a kind of neurodegenerative damaged disease.Results: Through the investigation of the glaucoma eyeball and aqueous humor samples, find that theβ-amyloid, Tau protein and Presenilin had expression and sediment on the glaucoma retina and optic nerve. Compared to the samples of control group, the expression level ofβ-amyloid is much higher in aqueous humor samples.Conclusion: glaucoma optic damage closely related toβ-amyloid and it might be a kind of neurodegenerative damaged disease. Aims: To determine the prevalence and identify associated risk factors for pterygium in an lderly Mongolian population at high altitude in Henan County, China.Methods: A population-based survey was conducted from June 2006 to September 2006. A tratified, clustered, random sampling procedure was used to select 2486 Mongolian people ged 40 and older. Pterygium was diagnosed and graded clinically as grade1(transparent),2(intermediate), and 3 (opaque).Risks factors associated with pterygium were evaluated with logistic regression models.Results: From 2486 eligible subjects, 2112 (84.9%) were examined. There were 378 people with either unilateral (n=228) or bilateral (n=150) pterygia, equivalent to an overall prevalence of 17.9% (95% confidence interval 16.3, 19.5). The prevalence increased with older age (chi-square test of trend P<0.001). Visual acuity decreased with higher group of pterygium ((?)~2=97.759, P<0.0001). Pterygium was independently associated with Schirmer test (65mm) (odds ratio 2.4; 95%CI, 1.9, 3.1), Tear break-up time (610 seconds) (OR 2.3; 95%CI, 1.8, 2.9), lower education level (<3 years) (OR 2.1; 95%CI, 1.4, 3.2),increasing age (OR 2.0; 95% CI, 1.4, 2.8) for persons 70 to'79, compared with 40 to 49,and other risk factors.Conclusions: The prevalence of pterygium in an older Mongolian population at high altitude is high, primarily because of ocular sun exposure and the other effects of the unique plateau climate, and representing an important health problem. People should be strongly encouraged to wear a wide-brimmed hat and/or sunglasses whenever they are outside. |
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