High-dose Chemotherapy Combined With Autologous Bone Marrow Transplantation Treatment Of Small Cell Lung Cancer

Of 9 patients with small cell lung cancer intended for high dose chemotherapy and autologous bone marrow transplantation (ABMT), 5 patients received ABMT while the other 4 were excluded due to contraindications. Primary tumours had been resected before inclusion in two of them (cases 1 and 2). Partial remission (PR) had been obtained in the other three (cases 3-6) before ABUT with the maximum residual diseases 1.5, 1 and 2 cm in diameter, respectively. Four cycles of induction or adjurent chemotherapy were conducted, and prophylactic cranial irradiation was given to 2 post-operated patients. The preparative regimen consisted of carboplatin 500-600mg/m~2, E-ADM 60-76mg/m~2 and etoposide 450-1200mg/m~2 which was finished within the period of 6-8 days followed by ABMT. Ca6e 4 achived complete remission (CR) while cases 1 and 2 remained CR status and cases 3 and 5 stable after ABMT. No patient died from acute treatment-related toxicities. However, case 4 developed severe delayed liver toxicity and in case 5 skin side effect and nerotoxicity in addition to severe diarrhea occurred with the dose of etoposide up to 1200mg/m~2, All 3 non-operated patients received chest irradiation (60Gy) ± prophylactic bilateral supraclavicular irradiation (40Gy). Case 1 died from unknown cause 4 months after ABMT. Case 2 developed secondary acute leukemia after disease free duration up to 19 months. Case 4 remained CR 6tatus whereas case 6 relapsed in primary site and case 3 with brain and bone me-...