Anti-cancer Effective Ingredients Gena Mellow A And Its Analogues Research

Howiinol A (1), a novel lactone isolated from the ethanolic extracts of the root and stem bark of Goniothamus howii Merr. (Annoaceae) in our laboratory has been shown to possess significant antitumor activities toward human tumor cells in vitro and in vivo and less toxicities. In order to provide more quantities of sample for further biological investigation, we have synthesized it in nine steps from a-D-glucoheptonic γ-lactone with an overall yield of 13.3%. The synthetic compound 1 is identical to the natural howiinol A by comparing its IR, ~1HNMR , MS and m.p., [ α ] d, thereby confirming its absolute configuration.OH OHOH OH OHOH OHIn order to study the antitumor activities of its stereo-isomers, we have also...