Rat C6 Glioma In The ~ 1h Magnetic Resonance Spectroscopy And Imaging Study | Posted on:2001-12-01 | Degree:Doctor | Type:Dissertation | Country:China | Candidate:H Yin | Full Text:PDF | GTID:1114360185496750 | Subject:Medical Imaging | Abstract/Summary: | PDF Full Text Request | Magnetic resonance technique, especially the magnetic resonance spectroscopy (MRS)technique,is developing quickly in recent years as an medical imaging research method. The best quality of MRS is that the MRS is the only noninvasive and in vivo means in detecting the changes in metabolism state and special biochemical compounds in living animal and human body, and that make it possible for us to observe the physiological and biochemical characteristic of brain neoplasma ,and the development of neoplasma.Brain neoplasma are common tumor, the incidence of brain neoplasma occupies 1.8% of all tumors. The most common of brain neoplasma is astrocytoma, it occupies 43.7% of brain neoplasma. The diagnosis and therapy of brain neoplasma is always the difficulty point and hotspot in clinically and basic research. In order to better understand the biology characteristic of astrocytoma, and look for the effective therapy method, the researchers look forward to setting up a steady and safe animal model of brain astrocytoma. The rat C6 glioma has the similar biology characteristic of human astrocytoma and the steady biology and pathology characteristic, and is widely used in tumor biology and experimental tumor therapy. Our work is the first using high magnetic field and high resolution spectrometer to detect the in vivo ~1H NMR spectroscopy in C6 glioma and the C6 glioma after treated with tumor necrosis factor alpha (TNF-a) in our country. We also observe the vascular endothelial factor (VEGF)that expressed in vascular endothelial and reflected the tumor growth rate. The work is important in prognosis and evaluating effect of the experimental drug therapy in brain neoplasma, and make a good foundation for clinical use of MRS in future. | Keywords/Search Tags: | Magnetic Resonance Imaging, Spectroscopy, High magnetic field, Brain, Rat, C6 glioma, Therapy, TNF-a, Immunohistochemistry, VEGF | PDF Full Text Request | Related items |
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