Prolactinomas Invasive Relevant Factors Analysis Of The Impact On GH3 Cell Proliferation, Invasion And Estrogen Receptor Antagonist

Objective To explore the significance of clinical features, the expressions of the estrogen receptor, the pituitary tumor transforming gene and the basic fibroblast growth factor in prolactinomas and to analyze the related factors to the invasiveness of prolactinomas and interrelationships in order to give evidence for the prediction of the behaviour of invasiveness.Methods Forty-six prolactinoma specimens were divided into the invasive group and the non-invasive group; the dates were collected including age, sex and prolactin in every patient. The expressions of ER, PTTG and bFGF were detected by immunohistochemistry and the ER-mRNA and the PTTG-mRNA were detected by the semi-quantization RT-PCR method, the results were calculated by the integral absorptance (IA). The invasiveness of prolactinomas was analyzed including age, gender and prolactin. Expressions of ER, PTTG and bFGF were decomposed between the invasive group and the non-invasive groups, the correlations among them were also analyzed.Results comparing with the non-invasive group, in the invasive group the age difference was not significant, but the sex and prolactin were correlated with the invasiveness of prolactinomas, the rate of female cases in the invasive group was 70.8 % (17/24) and it of male cases was 29.2% (7/24), which were significantly different(P...