Study Of Carbon Monoxide On The Role And Mechanism Of Lipopolysaccharide-induced Intestinal Injury In Rats

Intestine is in the abdominal cavity and contacts with the external environment. It is the main organ to obtain nutrients and it has the functions of immunity, barrier shield, metabolism, endocrine secretion, meanwhile, intestine is the largest depot of containing bacteria and it is the most important barrier shield to isolate internal environment from external environment. Intestine takes part in the physiological and pathological process of diseases with its distinct physiological function. Infection, shock and serious trauma can make the intestinal mucous membrane edema, erosion and ulcer, the enterocinesia weakens and even disappears. In the meantime, the microenvironment in the intestine is ruined, and the bacteria excretion and endotoxin excretion are dysfunction. Bacteria of intestine are disorder, conditional pathogenic bacteria acutely multiply and produce massive endotoxin. The endotoxin invades organs and circulation and it keeps mononuclear neutrophils activating which releases generous mediators of inflammation and cytokines. Mediators of inflammation and cytokines make the systemic inflammation more serious and organ dysfunction. All these pathological processes are the critical fundamentals in the multiple organ dysfunction syndrome(MODS).In the pathophysiological process of MODS, the intestine is target...