Experimental Study Of Different Doses Of Aspirin To Inhibit Atherosclerotic Plaque Progression

Part OneThe effects of different doses of aspirin on attenuating the progression of the atherosclerotic plaque in rabbitsBackground: The beneficial effects of aspirin on the primary and second prevention in cardiovascular and cerebrovascuar disease are verified by lots of linical trials, and these effects are thought to be the results of its anti-platelet effects, but its effects on attenuating atheroclerosis is not clear, the optimal dosage is not clear either.Objective: To evaluate the effects of low, middle and high doses of aspirin, which correspond to 100, 300 and 500mg/d in its clinical use, on the progression of aortic atherosclerotic plaque in rabbits.Methods: Fourty New Zealand White rabbits fed on a 2% cholesterol diet and 10% Albumin Bovine V injection were administered aspirin at 4mg·kg^-1·d^-1(Ld-ASA, n=10), 12mg·kg^-1·d^-1 (Md-ASA, n=10), 20...