Font Size: a A A

The Puzzle Herbal Computer Image Processing Technology To Establish Research And Educational Role Of Centella Asiatica

Posted on:1997-03-23Degree:DoctorType:Dissertation
Country:ChinaCandidate:X M LiuFull Text:PDF
GTID:1114360185469029Subject:Pharmacognosy
Abstract/Summary:PDF Full Text Request
By making use of the dominant position in pharmacy, electronic, engineering and computer sciences, and by converting learning and memory behavior into locus patterns of real time activity with the techniques of infrased, photography and computer- based auto - controlling, a computer - based auto - controlling and imaging -analysing processing system was first developed in this country for Step - Down, Step- Through and Water- Maze study in animal. Experimental results showed that the data collected with this system were identical with there collected manually. However, in addition to latent period(LP) and number of errors(Ne), this system can provide more information including the time of staying at error area(Te) and safe area(Ts), score of correct performance ( Score), and distance ( Dist.) and speed (Speed) of swimming, which have proved to be more systematic, scientific and reasonable for the judgment of learning and memory ability of the tested animal. The statistics prgram in the software will carry out analysis of variance, statistical tests and various kinds of outputs automatically for printing. Therefore, this system can be regarded as an advanced tool for pharmacological study of nootropic Chinese Medicinal herbs with high degree of automation, which can deal with large number of tested samples, and provide large amount of information, thus, with the computer - based autocontrolling and pattern analysing processing system, the experimental results obtained will further meet international standard of evaluation.The lesion of perfrontal lobes which was the first time set in mice showed that there was disturbance of acquisition and short term memory in the affected animals when performing complex spatial tasks. 2030% alcohol showed no obvious influence on retrieval, but the long - term application of alcohol ig can produce disturbance in acquisition in spatial task. Repetitive electric shock will induce obvious impairment of the ability to consolidation in passive avoidance task( Step- Through), but not in spatial discrimination task such as Step - Down and Water - Maze. The ability to remember the location of the plate and spatial orientation in Water - Maze was much lower in 16 month mice than that in mice aged 2 mounths. Scopalamine 25 mg. kg-1 ip induced disturbance in learning and memory acquisition and consolidation in spatial and dark - light discrimination tasks in mice. Sodium pentobarbital 20 30...
Keywords/Search Tags:Nootropic Chinese Medicine Herbs, Computer—Based Imaging, Processing Technique, Learning and Memory Disturbance, Animal Models, Centella asiatica
PDF Full Text Request
Related items