The Relationship Between Plasma Total Homocysteine ​​levels And Insulin Resistance Syndrome

OBJECTIVE To assess the changes of plasma total homocysteine (tHcy) concentration in NGT ,IGT, type 2 dianbetes without chronic complications (T2DM-I) and the groups of T2DM with chronic complications (T2DM-II).RESEARCH DESIGN AND METHODS The fasting plasma total homocysteine were measured in all subjects. At the some timem, BMI, WHR, blood pressure, liver and renal function(Urea Crea), OGTT (75g glucose), Total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol , Vitamen B12 and folate were also assessed, the value of tHcy were transformed in the natural logarithm form. RESULTS The value of tHcy in Ln in 4 groups were 2.258±0.062 in NGT, 2.275 + 0.062 in IGT, 2.821 ±0.102 in T2DM-I and 3.062±0.162 in T2DM-II. Respectively, with significantly difference statistically(F= 4.696 P=0.003). Difference derived mainly from T2DM-I vs NGT, T2DM-II vs NGT. No significant difference was not found between NGT and IGT(P=0.097).CONCLUSIONS The concentration of tHcy was increased along with the deterioration of impairment of glucose tolerance and elevated in patients with type 2 diabetes significantly, and particularly those with diabetes complications.