"heart Blood" Theoretical And Experimental Study

The initial theory "Heart produces blood" comes from "yellow emperor internal classic" and then, it identified with and developed by fhe following TCM doctors. Not until the Ming and the Qing dynasty did it fade and replace by the theory "Kidney essence give birth to blocd ". "Heart produces blood" includes two aspects :one is heart body generates blood and the other is heart vessels bring forth blood. Its physiological function manifests through "hua cfai ","xue jing sheng xue "and "help other viscera produce blood ". Its pa&plogic function manifests in "heart blood deficiency syndrome " whose representative formula is "Zhi Gan Cao Tang" and "stasis prevents new blood to be produced " whose representative formula are "Da Huang Zhe Chong pill" and the "Sheng Hua Tang"."Shen Fu Tang"(to warm heart Yang), "Sheng Mai Yin" (to nourish heart Qi and heart Yin ) and "Jia Jian Fu Fang Dan Shen Tang "(to expel stasis to help new blood to be produced ) ,the three formulas all can promote the endothelial cell cultured in vitro to secrete IL-6 and BL-11 ,both of which are important positive growth factors in the blood generation process.The three formulas mentioned in former paragraph don't have marked curative effect for the mice got blood deficiency syndrome after being eradiated by 3.5Gy '"Co Y -ray. But we can n marked curative effect after combining with the "Kan LiSheng Sni Tang "(to add essence to nourish marrow), furthermore, which are better than using "add essence to nourish marrow " singly. The curative functions manifest in the recovery of WBC, RBC and PLT in peripheral blood and the increase of the karyote ,CD34*and CD71* cells in bone marrow, which means all kinds of Hematopoietic cells in bone marrow proliferate and differentiate markedly, especially the erythron.So the mechanism of "heart vessels bring forth blood" mayrelate to the hemopoietic growth factor excretion of the endothclial cell. "Heart produces blood" this TCM fundamental theory may be shown during the process that the hemopoietic stem cell proliferate and differentiate into marrow naive karyotc and then into mature blood cell or be shown by protecting the mature blood cell.