The Gene Status Of EML4-ALK,EGFR,KRAS And C-Met Gene Amplification In Chinese Lung Adenocarcinoma

Object To investigate gene status of EML4-ALK, EGFR, KRAS and c-Met amplification in the Chinese patients of lung adenocarcinoma.Methods This study collected110surgical tissue samples of lung adenocarcinoma in a single institution (the first Xiangya hospital, Hunan, China), and examined EML4-ALK, EGFR, KRAS and c-Met gene amplification respectively with different methods.Results Eleven patients harbored EML4-ALK fusion gene, fifty-eight harbored EGFR mutation, four harbored KRAS mutation, and six harbored c-Met amplification. All genes were almost mutually exclusive. Therefore, approximately seventy-one point eight percents of Chinese patients with lung adenocarcinoma harbored the four genes.Conclusions This study examined the four genes in lung adenocarcinoma from Chinese patients. Since targeted therapies of EML4-ALK, EGFR, c-Met have obtained great improvements, this investigation indicated about seventy percents of lung adenocarcinoma of Chinese patients could successfully receive personal targeted therapies.