Based On Multivariate Statistical Analysis Of Chronic Glomerulonephritis Chinese Medicine Syndrome Research

Chronic glomerulonephritis refers to diffuse or focal inflammation changes, caused by different pathological type bilateral glomerular, and it's insidious onset, the course of length, slow development condition for a set of characteristics of the floorboard of glomerular disease. The clinical manifestations of glomerular disease are hematuria, proteinuria, hypertension, edema, referred to as chronic nephritis. The diseases can develop end stage renal failure, a heavy burden, so the positive early prevention is extremely important to the health finance.TCM was used to its unique diagnosis and treatment methods had an advantage in the treatment of the Chronic Nephritis in the Western counterparts to some extent, the recognition on the efficacy. This topic under the guidance of the TCM theory, basing on literature research combined with clinical epidemiological research and objective multivariate statistical methods, discussed the Chronic Nephritis syndrome distribution characteristics, and analyzed its etiology and pathogenesis machine, to provide a basis for possible clinical syndrome treatment attempts to standardize Chinese medicine.There are three parts in the article, including theoretical research, literature research and clinical studies.There are two parts in the first part. The first summarizes the Chronic Nephritis related concepts and the etiology and pathogenesis; The second first reviews the previous Syndrome standard of Chronic Nephritis, and then introduces research status of TCM syndrome, and syndrome with modern physical and chemical indicators.The second part is the literature research, mainly from the literature of the past 11 years, summarized up the common symptoms of chronic nephritis in the modern literature, and TCM syndrome distribution and extraction of Chronic Nephritis syndrome factor and clinical epidemiology of the questionnaire provided a reference.The third part is the clinical studies, this study observed 289 cases with Chronic Nephritis in patients with clinical data, from general information,laboratory tests and diagnostic message. Use of multivariate statistical analysis method of the common syndrome of chronic nephritis distribution characteristics and pathogenesis machine.Results:(1)The higher prevalence was of middle-aged and young; Women slightly higher than men, men and women with a ratio of 0.9:1. Patient age were from 79 and 18 years old. (2) In term of the general test index for, patients with Chronic Nephritis, blood pressure control was not ideal, the rise of CL, UA, CHO and TG is more, which often aggravate the original disease. (3) Clinical research showed that the common symptoms were fatigue, weakness, edema, five upset hot, low back pain, weak knees, dizziness, dry throat, nocturia, dry mouth, loss of appetite, sticky mouth slimy and etc. Common symptoms were the literature research exhaustion, edema, lumbar debility, loss of appetite, wan abdominal distension and fullness, loose stools, dry mouth, five upset hot, dry throat, chills limb cold and etc. The research results were basically the same, which main performance for the Spleen and Stomach symptoms and Shen symptoms. (4) The literature research finds that most of the syndrome type is the self, or not mentioned in the article Diagnostic Criteria.At present the confusion of syndrome standard, Chronic Nephritis syndrome differentiation of parting urgently need a relatively uniform standard. (5)The clinical research part,collecting cases material, established the four diagnostic information database, used multivariate statistical analysis methods to research the distribution characteristics of the syndrome. By clustering analysis, we can conclude that the disease could a syndrome factor kidney, liver, spleen, sexual disease syndrome factor is wet, heat, deficiency, blood stasis; Through the factor analysis shows that the disease the Chronic Nephritis syndrome factor may be in the kidney, spleen, ill sex syndrome factor mainly is empty, wet, blood stasis; Factor analysis also summarizes the basic chronic nephritis syndrome combination. (6)Through the literature research, the disease of syndrome factor frequency row of the top three were the kidney, spleen, the liver. Disease syndrome factor frequency row four were before qi, Yin deficiency, wet, blood stasis. (7)Through a variety of detection index and syndromes typical related analysis:F1 (mainly to hot and humid) and X6 (blood around white blood count) and X10 (neutrophils percentage) were related, F2 (mainly to Yang deficiency) and X10 (neutrophils percentage) negative correlation.Conclusions:(1) Through the exploratory factor analysis and cluster analysis to chronic glomerulonephr it is four diagnostic informat ion research clinic, from the Angle of statistics that its main disease syndrome factors are Spleen and Kidney, time sickness syndrome factors are Liver, Lungs, disease syndrome factors mainly were Qi deficiency, Yin deficiency and Yang deficiency, and disease syndrome factors mainly were dampness, heat and blood stasis. (2) The study finded that the hot and humid syndrome with peripheral white blood cell and neutrophils percentage was related, and Yang deficiency syndrome and neutrophils percentage was negatively related.It Suggested that these two laboratory parameters can be used as the basis of the clinical differentiation syndrome of the disease. (3)Used statistical analysis methods of dimension reduction thought to study TCM syndrome, and traditional method than the syndrome differentiation, is more advantageous to the syndrome in the research objective evidence of professional technology and combine to make the syndrome factor constitute more clear, consensus degree increase, and it can make up for the traditional methods of syndrome differentiation of subjectivity is too strong defects. It's the study of standardization of syndrome, one of the feasible way, which is worth further further discussed.