| Leukemia is a class of clonal hematopoietic stem cell malignant disease, bone marrow and leukemia cell proliferation and differentiation of barriers to unrestricted, normal hematopoiesis was inhibited, after leukemia cells enter into blood with the blood circulation infall into other organs and tissues, Acute leukemia (AL) is a severe illness, rapid development, high mortality of blood malignancies. Epidemiological survey, AL overall incidence of malignant tumors account for about 5%,2% of adult malignancies, more than 30% of malignant tumors of children and the incidence rate had an increasing tendency in recent years. Chemotherapy for leukemia treatment, bone marrow and peripheral blood stem cell transplantation, biological agents, gene therapy, the current chemotherapy still dominant. Chemotherapy has become an effective means of treatment of leukemia and has drawn increasing attention, with the rapid development of chemotherapy drugs and the way the progress of chemotherapy, Especially in refractory leukemia (Refractory acute leukemia, RAL) in the treatment, mainly to strengthen the chemotherapy regimen, but the great side effects of chemotherapy, chemotherapy drugs due to poor cell selectivity in killing tumor cells while normal cells have great destructive effect, tend to make people fall in resistance, which limits the adverse reaction to chemotherapy is more widely used. Therefore seek ways to reduce the toxicity of chemotherapy is paying more attention. The subject wish through observation, verification of compound Zhebei particles in the RAL chemotherapy to " Compound Zhebei particles " adjuvant chemotherapy treatment intervention has a good clinical drug safety and reduce the side effects of chemotherapy, Chinese medicine treatment RAL Display The characteristics and advantages.This paper divided into two parts, the first part,â… :the treatment of acute leukemia, the current treatment of leukemia with chemotherapy, bone marrow transplantation, biological modifier therapy, gene therapy, Chinese medicine treatment, etc., but chemotherapy is still the main treatment, and to explain induction of remission in acute leukemia, consolidate and strengthen the maintenance treatment of refractory acute leukemia in the Western medicine treatment;â…¡:chemotherapy side effects, brief chemotherapy commonly used in acute and subacute toxicity in refractory acute leukemia side effects of chemotherapy;â…¢:to reduce the toxicity of the method in Western and chinese medicine method. Compound Zhebei particles and the compound of the efficiency of attenuated, reversal of drug resistance. The second part of the clinical observations, the main purpose is the standardization of clinical trials to test the " Compound Zhebei particles " medicine based intervention programs around the treatment of refractory acute leukemia with chemotherapy anti-cancer drugs on subjects with acute and subacute toxicity Reactions to resolve the current medical treatment of common concern to anti-cancer benefit issues. RAL enrolled 238 cases of patients treated with chemotherapy+Compound Zhebei particles, the control group for the chemotherapy plus placebo. A randomized double-blind, placebo-controlled, multi-center clinical trial. Clinical trial programs in strict accordance with the provisions of the diagnosis, efficacy criteria, will meet the inclusion criteria of refractory acute leukemia were randomized grouped, and double-blind treatment for a period of chemotherapy treatment. According to indexing standards of the U.S. National Cancer Institute (NCI) to develop anti-cancer drugs in acute and subacute toxicity, the two cases of hematological, gastrointestinal, kidney and bladder, lung, drug fever, allergies, skin, hair loss, infection, heart, high blood pressure, low blood pressure, nervous system, constipation, pain, hearing, body mass index of 17, and increased blood clotting, blood sugar, B ultrasonic of extra fine item. Patients in the treatment of the first 14 days after a chemotherapy treatment, was interviewed by reaserchers on the subject, collecting the efficacy and safety assessments for a variety of data, fill in the case observation form (CRF), and real-time CRF tables in a variety of input test data. Results:The cases of ALP, gastritis, rhythm, peripheral nerve dividing comparison was statistically significant (P<0.05). Observation and detection of the remaining indicators were not statistically significant (P> 0.05). Tip Compound Zhebei particles adjuvant chemotherapy without increasing toxicity of chemotherapy drugs cases, chemotherapy, liver injury, gastric mucosa, rhythm and peripheral nerve has some protective effect. Conclusion:The observation of clinical trials, adjuvant chemotherapy Compound Zhebei particles, are not found in the RAL it can lead to increased drug toxicity in patients with cancer related to clinical evidence, and anti-cancer drugs on liver function damage (ALP), gastric mucosa, rhythm, and peripheral nerve has a protective effect. The research data from evidence-based medicine to answer in the field of cancer treatment, "whether the increased efficiency of Chinese medicine poisoning" in the long debate and widespread concern... |
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