Study Of Acupuncturing Taixi (KI 3) And Renzhong (DU 26) In MCI On Functional MRI

Background:Mild cognitive impairment is a kind of happened in the elderly between normal ageing and integratedly, with disease characteristics between dementia, a clinical condition. MCI patients'clinical manifestations of education degree with age and be independent of memory loss, working ability and efficiency descend, concentration drops, reduced ability to learn new things. But they have relatively normal daily living skills and cognitive ability and would not meet the standard for clinical diagnosis of dementia. In this state of patients exist beyond its age allowed by memory disorders, although cannot reach the diagnosis of dementia(AD) standards, but it often represent senile dementia early phase. Early detection, early diagnosis, early intervention to the mild cognitive impairment can prevent or delay the oceurrence and progress of dementia, which is of significance and an extremely important social, economic and medical value. Acupuncture in control this elderly patient is the special effect, but its central mechanism is lack of imaging basis.Objective:To study brain imaging characteristics and the relative specificity supersession of needling Renzhong(DU 26),Taixi(KI 3) and nonpoint by fMRI, and blood oxygen metabolism changes in brain areas for indexes. From different brain regions to explore the brain function in effect central mechanism from function change in patients with MCI needling Taixi (KI 3) and Renzhong(DU 26). From brain function definition to provide imaging basis acupuncture treatment of MCI.Methods:36 patients with MCI and 12 normal aging people were enrolled in this research.36 patients, including male 10 cases, female 26 cases, age 56 to 72 years old.12 normal cases, including male 4 cases, female 8 cases, age 55 to 76 years old. MCI patients were randomly divided into Taixi (KI 3) group, nonpoint group and Renzhong(DU 26) group and they were all 12 cases.36 patients with MCI all accord with the diagnostic criteria and right handed. Nearly a month not taking any affected cognitive function drugs, no functional magnetic resonance imaging (mri) scan the contraindication disease.Choose acupuncture point:select the right Taixi(KI 3) and Renzhong(DU 26). The nonpoint is chosen in the midpoint of attachment between Taixi (KI 3) and achilles tendon.Regular disinfection the skin, needle 15mm in the apoint by 0.35×25mm silver needle. Twisting 180°,turn amplitude frequency 60 times/min, lift inserted in fluctuation 1 mm amplitude. A block design including three blocks, resting state, rotating state and persistent after effect state.fMRI scanning takes approximately condition, and observe different treatment of brain function imaging characteristics. fMRI data were processing by the application of Matlab and SPM2 software. First realigned and normalized to Montreal Neurological Institute, then use half tall width (FWHM) 8mm x 8mm x 8mm for 3d gaussian function after standardization of data to make space smooth. According to hemodynamic response function hrf fixed effect analysis, then double sample t-test, inspection the difference between After effect of acupuncture and resting phase. Finally brain area activated will be transformed to the Talairach space.Results:1,The brain areas which blood oxygen for metabolic reduced including the left superior frontal gyrus (BA6),left cingulate gyrus (BA24),right superior temporal gyrus (BA38) before needling in MCI patients.2,The brain areas including the right cingulate gyrus (BA24),medial frontal gyrus(BA6),left postcentral gyrus (BA3) were activated when needling Taixi(KI 3) in MCI patients.3,The brain areas including the left inferior parietal lobule (BA40),left postcentral gyrus (BA2),left cerebellum anterior lobe culmen were activated when needling nonpoint in MCI patients.4,The brain areas including the right inferior frontal gyrus (BA45, 13),right middle frontal gyrus(BA47,10,6),right middle temporal gyrus (BA21), superior frontal gyrus (BA10),right precentral gyrus (BA6, 4),left superior temporal gyrus (BA38),left middle temporal gyrus (BA38),left Inferior temporal gyrus (BA20),right middle temporal gyrus (BA21),left anterior cingulate (BA24) were activated when needling Renzhong(DU 26) in MCI patients.Conclusion:The results suggest that MCI group of patients with normal before with acupuncture group compared leftsuperior frontal gyrus(BA6), left cingulate gyrus (BA24) and rightsuperior temporal gyrus (BA38) reduces blood oxygen metabolism, i. e. restrained by state. It proved that the AD prophase lesions, in mild cognitive barrier disease, the frontal and temporal lobes often have different degrees of lesions.Needle Taixi (KI 3) and Renzhong(DU 26) would specificity that enhance their blood oxygen metabolism. Needle Taixi(KI 3) and Renzhong(DU 26) target-based activates the lesions brain regions of MCI, and it regarding related brain regions have integrity adjustment effect. Frontal lobe and Parietal lobe have great correlation with cognitive function, which means they have great correlation with mind and brain. Frontal lobe and Parietal lobe have great correlation with cognitive function, which means they have great correlation with mind and brain. In addition, Chinese medicine theory is that brain sick when should be first treatment du meridian. The activation reaction of Taixi (KI 3) and Renzhong(DU 26), is with the meridian line and its contact Morrison is closely related to the viscera.This study found that needle Taixi(KI 3) and nonpoint contrast, can activate brain regions that more specific in cognition, emotion and memory. Using central BA40 and cortical generally feel area BA6 when needling nonpoint in MCI patients.Needle Taixi(KI 3) would activate bilateral brain and deep brain, and needle nonpoint only activate left brain. Needle Taixi (KI 3) has obvious regularity, but nonpoint hasn't. This, to a certain extent, proved "meridians specificity-brain related theory".