Investigation On The Csmb Reaction Separation Integrated Technology

With the resources, energy, environment and security issues becoming more prominent, the system consisting of production, energy consumption, emissions and safety and its optimization is becoming increasingly important in the petrochemical, pharmaceutical, light industry and food processing, production process. How to ensure efficient high quality output, and to achieve "energy saving, emission reduction, safety and green production" have become an important research topic, and focus research content in long-term technology development plan in china. In the above chemical process, reaction and separation are the most common and key parts. The integration and control of the reaction and separation is the most effective mean to achieve both efficient production and energy savings. In this paper, the CSMB, coupled/cascade simulated moving bed reaction-separation integrated technology was proposed. Through the integrated control of the multiple separation units and reaction units, the optimal point between the highest conversion rate and the best separation performance was found. This technology was successfully applied to the research products of oligosaccharide, mannitol and other resources. The multi-component separation and continuous integration production was achieved. The resulting products have been optimized in processing power, energy efficiency indicators, productivity, solvent consumption, product performance and other aspects. The targets of a fine resource extraction, waste regeneration, green processing and optimization of energy efficiency and emission reduction were achieved. The main research content and innovations are:(1) Based on study of continuous chromatographic separation and principle of controlled electrochemical reaction, the novel CSMB coupled/cascade simulated moving bed reaction-separation integrated technology was proposed, which was constituted by different functional units. The separation unit was composed with different blocks formed by series-parallel columns. Through the reasonable control algorithms and the combination design of the valve, the series/parallel of the separation units and reactor units were formed, and then the division of the various functional blocks were achieved. For different product requirements, using the proposed algorithm and control process, the regional-type simulated moving bed separation coupling system and multi-cell reaction-separation integrated system were established. Through the continuous integration cycle run, the balance of the highest conversion rate and the best separation performance was achieved, and the optimized integration of reaction and separation was realized. When the system working in the optimum condition, the high efficiency, high precision and high-quality preparation can be met, at the same time, the energy consumption and organic solvents emissions can be effectively reduced. Then the mechanical and electrical integration production of multi-component can be realized.(2) Based on the basic theory of the chromatographic separation and chemical reaction mass transfer, the chromatographic separation parameters involved in the model were determined. The single column, two series columns, multi-columns in series and multi-fractionation chromatography separation models were established and solved through FEMLAB soft. The modeling solution in good agreement with the experimental results, then the separation control time point were accurately given. Based on the separation model, the reaction-separation coupling model was established, and the optimal coupling point was determined. Column length, flow rate, injection volume and other factors in coupling reaction and separation technology were considered and optimized, and then optimization measures were given.(3) According to the above design ideas, model analysis and key process tests, a versatility and opening reaction separation integrated equipment was exploited. A novel controlled electrochemical reactor was designed and fabricated. Through the real-time conductance, current and pH test, the reaction process can be sensed and controlled. According to the multi-component separation requirements, a separation system of series/parallel multi chromatograic columns was developed, through a different combination of the valve switch, the regional-type simulated moving bed separation coupling system and multi-cell reaction-separation integrated system were realized. Finally, through the transportation of the programmable constant pumping, the control system composed by the 1PC-PLC, the software configured with MCGS, testing by refractometer, bio-sensing analyzer and HPLC, the CSMB integrated equipment coupling reaction and simulated moving bed separation was established.(4) Using the proposed CSMB integrated technology, in the designed reaction-separation integrated platform, the preparation of mannitol and chitosan were researched. In the preparation of mannitol, the mannitol was prepared by electrochemical reduction and integrated with the regional-type simulated moving bed separation coupling method. In the preparation of chitosan, the electrochemical degradation of chitosan were carried out, and two multi-cell reaction-separation integrated methods were used, base on single column and two columns in series as the basic separation unit. The best process route and high-quality objectives were obtained in the above preparation, and process energy and emissions were quantitative analyzed. The results show that, for multi-component mixture, the reaction-separation integrated technology is highly efficient separation method to obtain high purity products. And its continuous and efficient integration of production can greatly save energy and reduce environmental pollution caused by organic solvents, and its R & D closely linked to the current "high production", "green chemistry" and "energy saving" and other important development directions, with a high application value.