The New Strategies For The Prevention Of Stroke In Hypertension Rats

Object: To investigate the new targets for the preventing of stroke in hypertension and its mechanism, and propose the new strategies for it. Results and Conclusion: Arterial baroreflex (ABR) function is a new independent predictor for stroke incident in hypertension, and restoration of impaired baroreflex sensitivity (BRS) alone with low dose of ketanserin delayed stroke death. Caloric restriction (CR) prevents the end organ damage, extends the life span of SHR-SP, and delays the occurrence of stroke. SIRT1 expression, arterial baroreflex function and apoptosis might involve in the effects of CR on stroke death. The expression of SIRT1 was inhibited by impared ABR function by sinoaortic denervation (SAD) operation. The prolonging of life span by CR was also inhibited by impared ABR function.