Experimental Study On Chymase Activity Of Atherosclerotic Plaques

BackgroudAcute cardiovascular disease and cerebrovascular disease are two common and multi-onset diseases, which have serious effects on the health of human beings, and their pathological basis is atherosclerosis (AS) .Extensive evidence supports that endotheliocyte, smooth muscle cells, macrophages , T lymphocyte and mast cells play a vital role in the development of atherosclerosis. Recent studies show that mast cells have a close relationship with atherosclerosis due to their secretion of inflammmatory factors such as chymase, histamine and other cytokines. Research shows that chymase prompts development of atherosclerosis through the following ways: (1) Increasing Ang II forming of vascular tissues by activating renin -angiotensin system (RAS), which prompts atherosclerosis development.(2) Accelerating atherosclerotic plaques development by activating inflammatory factors of atherosclerosis process; (3)Accelerating atherosclerotic plaques development by degradating apolipoprotein AI, which prevents foam cells from extraversing cholesterol. (4) Prompting plaque unstable by directly proteolyzing matrix ingredient of plaque cap such as connective protein, laminin , resilin, collogen IV and V, which causes caps of plaque thinner.(5)Making the plaque cap thinner by activating MMP-1, MMP-2, MMP-3, and MMP-9 and causing the plaque vulnerability.(6)Exerting a destabilizing effect on the plaque by inducing vascular smooth muscle cells(VSMCs)apoptosis and inhibiting VSMCs secretion by degradating fibronectin and activating inflammatory factors. (7) Augmenting shear stress acting on the arterial wall through many ways, which causes...