Study Of Associated Factors Affecting Formation Of Intracranial Aneurysms

Objective To study the risk factors associated with the formation of sporadic intracranial aneurysms patients in Chinese. Methods 251 patients with intracranial aneurysms and 338 control patients from January 2003 to Match 2005 hospitalized in huashan hospital were collected. Single factor and logistic regression model were used to analyze the association between intracranial aneurysms and patient age and sex, cigarette smoking, alcohol or cocaine consumption, history of hypertension, coronary artery disease , diabetes mellitus and heritage connective tissue disease, the value of fasting blood glucose and blood fat. Results The age of 163 intracranial aneurysms patients(64. 94%)was from 40 to 60. Sex (odds ratio:1. 41, 95% confidence interval:1.01-1. 96), cigarette smoking (odds ratio:1. 81, 95% confidence interval:1.30-4.16), hypertension (odds ratio:2.32, 95% confidence interval:1.06-3.10) and the value of fasting blood glucose were associated with intracranial aneurysms significantly (P<0. 05) . A negative association exist between intracranial aneurysms and alcohol consumption, coronary artery disease, the value of blood fat (P>0. 05) . Using logistic regression analysis, we identified female and age were significant risk factors for the formation of sporadic intracranial aneurysms. ConclusionThe age of sporadic intracranial aneurysms patients in Chinese was from 40 to 60 mostly. Female, cigarette smoking, hypertension seemed to be independent risk factor for the formation of sporadic intracranial aneurysms patients in Chinese and sex was the most prevalent one. The elder age could add the effect of other risks.Part TwoRelations between intracranial aneurysms and hemodynamic changesObjective Study the Relations between intracranial aneurysms and connutual hemodynamic changes. Methods Cerebral DSA findings in 514 patients hospitalized in Huashan Hospital from March 2004 to July 2005 were retrospectively analyzed. All cases were screened by internal carotid artery and vertebrobasilar artery angiography. Relations between cerebral aneurysms and connutual hemodynamic changes were evaluated by radiological changes. Results The study population consisted of 191 patients with 200 intracranial aneurysms and 323control cases. 281 cerebral blood vessels with hemodynamic changes were seen . In 200 cerebral aneurysms, 85(42.5%) were related with original hemodynamic changes . In 323 cases without cerebral aneurysms , blood vessels with hemodynamic changes resulted from original variations were 114. In 56 aneurysms of the anterior communicating artery , 41(73.21%) were companied with A1 dominat signs .There was significantdifference (P<0.05) odds ratio : 10. 43 (95% CI: 5. 52-19. 72) . In 46 aneurysms on the junction of internal carotid and posterior communicating artery, 27 (60%) were seen getting blood supply from internal carotid artery or from the mixture. There was significant difference too ( P<0.05 ) odds ratio :11.43 (95% C: 6.15-21.26). Conclusions Hemodynamic changes is an significant factor for intracranial aneurysms. Subsequent hemodynamic changes resulted from original diseases are not associated with aneurysms. There is much more important for A1 dominant signs to anterior communicating aneurysms and hemodynamic changes of the posterior circle of Willis to internal carotid and posterior communicating artery aneurysms on the ipsilateral internal carotid-posterior communicating artery junction.Part ThreeThe study of single nucleotide polymorphisms in association genes of intracranial aneurysmObjective Analyze single nucleotide polymorphism (SNP) in association genes of sporadic intracranial aneurysms patients in Chinese. Methods 348 patients with intracranial aneurysms and 383 control patients hospitalized in huashan hospital from May 2003 to May 2005 were collected and SNPs in endoglin and elastin were elect to examine as the association genes of intracranial aneurysms. 9 SNPs in endoglin and 18 SNPs elastin were genotyped by Taqman technology of 7900HT Sequence Detection System. We have evaluatedtheir allele and haplotype association with intracranial aneurysm. Results There was no evidence of linkage between SNPs of endoglin and elastin and intracranial aneurysms by analysis their allele (P>0. 05). We found no allelic association between endoglin polymorphism haplotype and intracranial aneurysms. There were three haplotypes association with intracranial aneurysms(P<0.05). Conclusions We provide evidence that there is no association between endoglin polymorphism haplotype and intracranial aneurysm and indicate that elastin seemed to be a susceptibility gene for sporadic intracranial aneurysms patients in Chinese.