Study On Intestinal Immune Suppression And Molecules Mechanism In Mouse After Severe Burn

Background and Research StrategyMultiple organ system failure (MOSF) is the leading cause of mortality following severe trauma, burn, hemorrhagic shock and infection. Alterations in intestinal barrier/immune function appear to contribute to the dysfunction of other organs after severe injury. According to the gut hypothesis of MOSF, the gut is a reservoir for pathogenic bacteria and endotoxin which may contribute to increased susceptibility to infections and sepsis after trauma and hemorrhagic shock. Intestinally derived bacteria or endotoxin serve as triggers to initiate, perpetuate, or exacerbate the septic state and thereby promote the development of MOSF. Under physiologic conditions, the intestinal mucosal barrier typically serves a major role in the local defense against bacteria entry and the translocation of endotoxin to the systemic circulation. However, injury conditions such as burn may disrupt the normal intestinal barrier functions and thus may allow increased bacterial infiltration to mesenteric lymphnodes (MLN) and other extraintestinal sites including spleen, liver, lung, and blood. This passage of bacteria from the gastrointestinal (GI) tracts to extra intestinal sites has been termed bacterial translocation. Three major factors could contribute to bacterial translocation: 1) physical disruption of mucosal barrier, 2) intestinal overgrowth of bacteria, and 3) suppression of the immune defense.Although increased intestinal permeability may contribute to...