An Experimental Study Of Apoptosis Of Lung Cancer Cell Induced By Arsenic Trioxide And Its Mechanism

The concept of " Apoptosis " was put forward nearly 30 years ago. In the eucaryotic multicellular body the cell number is controlled by a balance between the cell division, cell proliferation and the cell active death as well. Such a balance holds an outstanding significance on the development of the organism as well as the maintenance of a normal structure and function. Just like that of the cell division, the cell apoptosis is also one of the basic features of cellular life and being controlled by the highly nonrandomized genes. The comparative stabilization of the inner environment of the body is guaranteed by the dynamic balancing of both of them. Recent research works indicate that there is a significant correlation between the development and growth of the malignant tumor and an unbalancing of cellular proliferation and apoptosis. A blockage of cell apoptosis had been found in many maligmant tumors.Lung cancer is a malignancy with a predominant morbidity and mortality. It gets to be a menace not only to the health but also to the existance of human being because of the fact that the elevation of the amplitude of its mortality being the first among all the tumors. The development of lung cancer is a complicated process, most likely it is the result of interaction between a group of environmental and hereditary factors. A vast amount of studies indicate that many gene changes are concerned during the course of development as well as the growth of lung cancer, so do the cell apoptosos genes however.The Fas, bcl-2,bax and P53 are all relative apoptotic genes. The...