The Effect Of Immunosuppression To Prevent And Treat Neuropathic Pain In Rats

Experiment 1 The Effect of Pre-injuryImmunosuppression to Prevent NeuropathicPain Development in RatsObjective: Neuropathic pain is one of the most common types of chronic pain that is difficult to treat due to the unclearness of the underlying mechanisms. A great number of studies have indicated that immune reaction caused by nerve injury might play an important role in the pain development. Non-specific immune suppression with non-steroid anti-inflammatory drugs attenuates neuropathic pain. A recent study implicated that the immune reaction following nerve injury is mediated by lymphocytes. Animals developed less pain in nude rats with mature T lymphocytes deficient compared with their heterozygous littermates. In addition , passive transfer of type 1 T cells into nude rats enhanced the recipients' pain hypersensitivity to a level similar to that of heterozygous donor rats. Therefore, we propose that powerful T-cell suppressing drug cyclosporine A may significantly inhibit the neuropathic pain development following nerve injury. This study observed the preventive effects by starting CsA injection before the nerve injury .Methods: In the experiment, 20 SD rats were randomly accepted CsA (6mg/kg i.p.) or same volume of saline. At 5th day, chronic constrictive...