Liposomal Quercertin's Efficiently Inhibit Growth Of Solid Tumor In Murine Models

Objectives: Quercetin (3,3',4',5,7-pentahydroxyflavone) is a naturally ocurring flavone found in the plant kingdom. It is a component of most edible fruits and vegetables with the highest concentrations being found in onions, apples and red wine. Quercetin has many biological activities, such as antitumor, anti-proliferatic effects on a wide range of human cancer cell lines and inhibitions of glycolysis, macromolecule synthesis and enzymes. Clinical trials exploring different schedules of administration of quercetin have been hampered by its extreme water insolubility. Liposomes have previously been used as carriers for delivery of a variety of drugs, including antibiotic, antifungal, chemotherapeutic drug, and biological agents. As carriers for anticancer drugs, they have been shown to reduce side effects, improve the water soubility, biodistribution, and metabilition of those drugs After coating the liposome surface with inert, biocompatible polymers, such as polyethylene glycol (PEG), it form a protective layer over the liposome surface and slow down liposome recognition by opsonins and therefore subsequent clearance of liposomes, so that liposome has a long-circulation time and provides slow release of an encapsulated drug, resulting in sustained exposure to tumor cells...