The Potential Role Of Cycloxygenase-2 And Mechanism Involved In The Development Of Acute Pancreatitis Associated Lung Injury, A Pilot Experimental Study

Background & AimsAcute pancreatitis, pathologically characterized by interstitial edema and hemorrhage, vacuolization, aciner cell necrosis as well as inflammation, can present with varying degrees of severity and with unpredictable clinic sequel, it is frequently associated with systemic inflammatory response, About 20% patients with acute pancreatitis develop servere condition (multiple organ dysfunction or failure) with a mortality rate over 40%. For this reason, severe acute pancreatitis (SAP) is still categoried as a common and severe disease vital to human health.Acute pancreatitis-associated lung injury (APALI),with high incidence in acute pancreatitis, is a systemic sequelae of vital importance,and adult respiratory distress syndrome (ARDS),a severe...