Design And Development Of New Integrative Interlocked Biomaterial For Bone And Cartilage Repair

Cartilage diseases caused by trauma, chondritis, arthrophlogosis and chondromalacia patella are common in department of orthopaedics. With the development of the society, defects in cartilage tissues increase dramatically in clinic because of the growth of trauma and the aging of population. Today there are millions of patients suffering from cartilage diseases throughout the world. The World Health Organization has declaimed that the 21st century is the century of bone and joint.Since 1743, when Hunter discovered that cartilage after being damaged cannot repair by itself, no ideal approach has been found to repair cartilage defects. According to the results of numerous researches, the self-repair ability of the arthrodial cartilage is quiet limited. Cartilage defect less than 3 mm in diameter can be partly or completely repaired by itself, while defect more than 3 mm in diameter can not be self-repaired. In the case of huge and deep defect in the arthrodial hyaline cartilage, it is very difficult to repair and after a long time would result in arthrophlogosis.Every year in China, 100,000 people suffer from cartilage defects caused by trauma, nearly 120 million patients, 9.6% of the population, suffer from arthrophlogosis and about 50,000 patients need to accept the implantation of knee joint. Therefore, the application of cartilage prosthesis and cartilage tissue engineering will improve the life quality of a great number of people and reduce the medical cost of the society. To catch up with the advanced science and technology of...