Mechanism Of Antiandrogen Flutamide Causing Hypospadias On Pregnant SD Rat

Hypospadias is one of common diseas in pedo-urinary surgery from main male. According to overseas statistics,its incidence is 1 / 250-1 / 300 in liveborn infant and 2-3 / 1000 in China. In the past 30 years,its incidence have increased almost one time.This do not explain apparently by inherit.Of course,we do not exclude the cause of the system of monitoring and reporting, we think that the reason of the rapid increasing case should be considered.Now,many scholar put the attention on environment in genito-urinary domain.They consider that the widespread pollutant may produce the increasing reason of hypospasias in environment.But,the elevated mechanism of biological effect is not clear yet in the world.Many suppose that environmental polluant may alter the factor of endocrine in animals to result in hypospasias.It is proved that people usually ingest and contact antiandrogenic substance,such as insecticide,by-product of plastics,medicine etc.In a way environmental polluant can explain the elevated reason of hypospadias in the world.Recently,some investigation manifest antiandrogenic substance can compete AR with androgen,many of them are the antagon of AR.These substance are called the environmental antiandrogen.It is known to all that androgen puts a key role in the expression male phaenotype and AR puts a impotantance in the effect of mediating androgen in sex differentiation and sex development.The exposure of environmental antiandrogen may produce harmful effects all the more on male reproductive systerm.Therefor,people pay close attention to it.Many studies have shown that antiandrogen can impair the reproductive functions of male animals through breaking the internal sex hormone...