Studies On Cytopathic Effects And Genome Gene Expression Profiling Of ECV304 Cells Infected With Human Cytomegalovirus

The human cytomegalovirus (HCMV) is the most common pathogen for causing congenital infection. HCMV infection are over 80% in population, and primary infection during pregnancy as a source of fetal infection was suggested when there exist primary infection in pregnant women. As the leading infectious agent causing birth defects, HCMV was regarded as one of five top biological teratogenic agents, which also included Toxoplasmosis, Rubella virus, Herpes simplex virus and Syphilis. The impacts of HCMV has increased in recent decades due to the rise risk in organ allografting, immunosuppressive treatment, radiation damage, malignant tumor, and human immunodeficiency virus (HIV)-infected patients. There has been showed that HCMV infection rate various in different transplantation were 8%, 29%, 25%, and 39% in renal, liver, heart and lung grafting, respectively. Therefore, understanding of the molecular pathogenesis and pathology of HCMV is a key element in development of strategies for prevention of HCMV infection and is important for improving the population quality.HCMV denominated as human herpes virus 5 (HHV-5) is a member of the beta-herpesvirus group. The virion of HCMV is about 200 nm in diameter containing a 100 nm diameter icosahedral nucleocapsid. The DNA genome surrounded by a proteinaceous layer defined as the tegument or matrix, which, in turn, is enclosed by a...