Mechanism Study On Osteosarcoma Metastasis Regulated By Integrin

1. BackgroundOsteosarcoma is one of most common primary malignant bone tumor. The morbidity of osteosarcoma takes 21 to 33 percent of all malignant bone tumors. The disease usually happens on teenagers, 68 percent are between 11 to 20 years old. The most common morbility location is around knee. In fact, 60 percent osteosarcoma was happened on distal femur or proximal tibia. The traditional standard surgical therapy was amputation, but the metastasis still happened on 90 percent even after amputation. From the 1970's, with the development of high dose neo-adjuvant chemotherapy, imageology diagnosis, and tumor surgery, the therapeutics of osteosarcoma was improved notablely. The survival rate of 5 year was increased from 10 percent to more than 50 percent. In some famous medical center, the survival rate reached 80 percent. According to statistics, mico-metastasis, especially lung metastasis, was happened in more than 90 percent osteosarcoma patient when they came to the doctor for the first time. In the end, it is not localized tumors that kill people with osteosarcoma, it is process of metastasis - an incredible 90 percent of the time. Hardly, according to a FORTUNE examination of NCI grants going back to 1972, less than 0.5 percent of study proposals focused primarily on metastasis. Of nearly 8,900 NCI grant proposals awarded in 2003, 92 percent did not even mention the word metastasis. Exploring the mechanism on osteosarcoma metastasis is becoming...