Studies On Expression And Regulated Mechanism Of Four Tumor Suppressor Candidate Genes In NPC

Tumorigenesis is a multistep, multistage process involving multiple genes. In fact, it results from accumulation of genetic changes (such as mutation, LOH and chromosome breaking) and epigenetic changes (such as DNA methylation) in genomic DNA. Epigenetic is the main mechanism which regulates gene expression without sequence changes.DNA methylation is the only known covalent modification of DNA molecule. It is accomplished by transfer of the methyl group from S-adenosyl methionine to 5 position of the purine ring of cytosine. It plays an important role in the regulation of genetic information. It was shown that the same tumour cells which were described to have the global genomic hypomethylation frequently have local regions of dense hypermethylation. Aberrant promoter methylation contributes to tumorigenesis through inducing transcriptional suppression and inactivating tumor suppressors.Nasopharyngeal carcinoma (NPC) is a malignancy particularly prevalent in Southern China and Southeast Asia. Various studies indicate that the development of NPC is a multistage process involving multiple genes. Genetic predisposition and epigenetic alterations, Epstein-Barr...