The Role And Mechanism Study Of Inflammation-Induced Peripheral Sensitization In The Pathogenesis Of Visceral Hypersensitivity

BackgroundVisceral hypersensitivity is an important character for patients suffering from functional gastrointestinal disorders. There is no histological abnormality detectable in these patients. The anal-rectum manometry revealed that the primal sensation threshold and the maximal sensation threshold decreased. Furthermore, even some physiological stimulation could result in the symptoms of gut dysfunction in these patients. Recently study suggested that the gastrointestinal hypersensitivity was closely related with the abnormal gut afferent pathway. Many receptors in gut parietal responsible for different kinds of stimulation in the gut were sensitized. On the other hand the normal visceral afferent signals projected to spinal and brain level were magnified leading to the hypersensitive reaction of the gut.The precedent infection in the gut plays an important role in the pathogenesis of functional gastrointestinal disorders. About 1/3 patients once experienced some gut infection in clinical practice. At least some symptoms as abdominal pain and diarrhea were caused by the inflammation damage to the gut nervous system...