Effect Of Acute Hypotension On Release Of Amino Acids In The Medial Vestibular Nucleus Of Anaesthetized Rats

To understand the neurochemical mechanisms underlying the impact of blood pressure on vestibular function, we determined the levels of amino acids such as aspartate, glutamate, glutamine, glycine, taurine, alanine in the medial vestibular nucleus (MVN) in anesthetized rats. Acute hypotension was induced by hemorrhage from the femoral artery. Main indexes determined in the current study were:1. The levels of some amino acids in MVN of normal control rats.2. The levels of some amino acids in MVN in the rats with acute hypotension induced by hemorrhage (0.5ml, 1.5ml, 3ml) from the femoral artery.3. The levels of some amino acids in the MVN of rats that were pretreated by infusing 2% lidocaine into middle ear to obstruct uni-periphery vestibular organ.4. The levels of some amino acids in the MVN of rats which were pretreated by infusing 10mg arsanilic acid into the tympanic cavity to obstruct uni-periphery vestibular organ.5. The levels of some amino acids in the homonymy and the opposite side MVN of the hypotensive rats which were pretreated by infusing 2% lidocaine into middle ear or 10 mg arsanilic acid into the tympanic cavity to obstruct uni-periphery vestibular organ.6. The levels of some amino acids in the homonymy and opposite side of MVN...