A Pharmacological Evidence Based Analysis Of The Effective Ingredients Of Qingkailing, An Injection Of Taditional Chinese Medicine, On An Animal Model Of Acute Lung Injury By Inhalation Of Perfluoroisobutylene

Perfluoroisobutylene (PFIB), a colorless gas at normal temperature, is a kind of fluoro-olefin that is regarded as the most potent in all of the pulmonary edemagenic chemicals. It is usually generated as a by-product during the manufacturing or the pyrolysis of polytetrafluoroethylene (PTEE), which is widely known by its trade name Teflon. The accidental inhalation can cause severe pulmonary edema, and even death because of pulmonary congestion. No specific antidote or successful therapeutic measures are currently available.When severe acute respiratory syndrome (SARS) was prevailed at the Chinese mainland in 2003, most of patients with the epidemic disease were suffered with acute respiratory distress syndrome (ARDS), charactered by diffuse alveolar damage and pulmonary edema. In consideration of the fact that a standard protocol, i.e., at what stage in the process of ALI/ARDS and at what dosage should corticosteroids be administrated in the management of a patient, was still highly controversial at that time, and that frequently reported adverse effects, such as femoral head necrosis, central obesity, which, in fact, were proved to be a problem in many of the SARS patients that received corticosteroids treatment, we planed to find some effective herbal drugs by screening of traditional Chinese medicines (TCM) which have been approved and marketed by the State Food and Drug Administration (SFDA). Pulmonary edema induced by PFIB inhalation was used as a pharmacological experimental model to mimic that of SARS. The results showed that Qingkailing Injection (QKL) administration could, dose dependently, reduce wet lung to body weight ratio (100.6±9.8 Vs 141.8±28.6, QKL group Vs PFIB group), total protein...