| Ionizing radiation (IR) can lead to cell/tissue damage by many mays, among of which DNA double-strand breaks induced by IR is the key way to kill cell. A series of genes can be induced by IR, sequentially determine the cell survival or death. Bone marrow, a radiosensitive tissue, palys an important role in hemopoiesis.So far, the detail damage mechanism of bone marrow induced by IR is not clear. Additionally, studies of single or several genes can not meet the systemic requirement. For deep-understanding of the possible mechanism which is related to IR-induced damage, high-throught techniques are needed.Based on the fact mentioned above, we analyzed the differentially expressed genes at postirradiation 6h, 1 weed and 2 weeks in mouse bone marrow using gene expression profile techniques. Furthemore, we focused on investigation of some genes. All the results are as follows:1 . From microarray data, we obtained that there were 1560 , 1006 and 379 genesshowed different expression at postirradiation 6h, 1 week and 2 week respectively. Among them, there were 32 genes showed difference all the time.2 . SAPK/JNK and p38MAPK pathways which both are the branch of MAPKpathway were restrained remarkably at 6h after IR. Meanwhile, downregulation of CDK Regulation of DNA Replication and G1/S Check Point pathwaies were also observed. However, it was clearly observed that p53 pathay was selectivly activated, which is associated with downregualtion of SIRT1 expression.3 . Both complement Pathway and intrinsic Prothrombin Activation Pathway mightbe downregulated beause of decrease in mRNA level of some importan molecular component of pathway. Of note, some mRNA of genes belongs to the...
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