Association Study Between Human FCγR Family Genes Single Nucleotide Polymorphism With SLE In Chinese Han Population

Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies and the formation of immune complexes (ICs), and the deposit of autoantibodies and ICs can lead to inflammation and injury of multiorgans. SLE, the clinic manifestations of which are variable including glomerulonephritis ,dermatitis,vasculitis, epileptic seizure ,arthritis and so on ,is an type of complex diseases and also regarded as the multifactorial disease. Up to nowadays, although there have been a lot of hypothesises about the etiology and pathogenesis of SLE such as the immunology theory, the genetics theory and the theory of the interaction between environment and genetics, the exact development mechanisms of SLE are elusive. In the recent years, the genetic factors have been demonstrated to play an important role in the onset of SLE. And through linkage analysis the eight genetic loci were found to be associated with the susceptibility to SLE.The aims of the present study are to through the large scale epidemiology survey of families with SLE and making use of the research results of Human Genome Plan the study of ours was aimed at searching the genetic relationship with SLE of specific single nucleotide polymorphisms(SNPs) and haplotypes in the susceptible genes (immunoglobulin receptor gene family) at some susceptible loci of Han ethnics among...