The Experimental And Clinical Study Of Prefabricated, Individulized Titanium Alloy Implant For The Reconstruction Of Cranial Defect Based On Computer Data And Rapid Prototyping Technique

Cranial defect of different causes is a common disease in clinical practice, which is seriously harmful to patient's body and mind and have high incidence. The surgical reconstruction of extensive defect has always been a challenge for craniofacial surgeon for its complicated anatomical structure and irregular three-dimensional curvature. Traditional methods not only require long contouring time, but also largely depend on the experience and skill of surgeon. Even so, the integrality of cranial cavity could only be restored in some degree, and the aesthetic result is dissatisfactory. As a frontier of advanced industry technique, rapid proto-typing , combining with modern computer, CT and biomaterial, is now widespread in medical practice. This research was aiming to: 1.explore the method of prefabricated, individualized implant for reconstruction of cranial defect, by virtue of the techniques of computered tomography, computer imaging processing, rapid prototyping and exact foundry of titanium. 2. Access its bio-capability in clinical application.In experimental part, the animal model was established by creating defects of random size and shape on parieto-occipital zone of goats, without damaging of dura mater. Basing on data resource from EBCT (Electronic Beam Computered Tomography) continuous thin-layer scanning, the individualized implant was prefabricated by three dimensional reconstruction, a serial disposal of CT imaging, three dimensional curved reconstruction, computer aided design, prototyping manufacture of three dimensional cranial model and individualized implant, and exact foundry of titanium alloy. After implanted in the area, the following items were observed: (1) Tissue reaction adjacent to titanium alloy implant in different period...