Study On The Relationships Between LIF, Pinopodes And Endometrial Receptivity

Implantation is one of the most complicated and interesting biological events. Dynamic changes occur between the embryo and the receptive endometrium during this process. Ideal "cross-talk" between the embryo and the receptive endometrium plays important roles and interact for the successful attachment and implantation of the embryo. The endometrium is receptive for the embryo and presents an implantation window for a limited time. Implantation failure is considered to be the major factor limiting the success of infertility treatment including in vitro fertilization embryo transfer (IVF-ET). Endometrial receptivity is one of crucial factor for successful implantation.Many factors have been found to be associated with endometrial receptivity. The research on the uterine receptivity focuses on two aspects: molecular factors and endometrial morphology. LIF is one of the molecular factors. Pinopodes is the marker of the change in endometrial morphology .LIF is a secreted glycoprotein first described as a factor that induced the differentiation of mouse myeloid leukemic Ml cells into macrophages. It is a member of a cytokine family whose members often have overlapping functions. The effects of LIF in many physiologic systems include proliferation, differentiation, and cell survival. LIF is also considered to be associated with many reproductive processes, especially for implantation. Evidence for a role of LIF in implantation comes from female transgenic mice, homozygous for LIF gene deficiency, in which embryo implantation did not occur. Lack of implantation was not due to defects in the embryo, because implantation of...