Design, Synthesis And Catalytic Performance Of Novel Chiral Catalysts Derived From Cinchona Alkaloids

Quinine has been known as an active antimalarial drug for many years. However, in the last two decades, Cinchona alkaloids have become more attractive due to their successful applications in asymmetric synthesis. They have emerged as powerful chiral auxiliaries, resulting in some well known landmark developments. More recently, these alkaloids themselves have been shown to undergo some remarkable transformations that are rapidly widening perspectives in the chemistry of Cinchona alkaloids, embracing both basic and applied science. The unique features, such as stereochemical diversity, well developed conformational minima not encountered in conventional organic substrates, hydrophilic pockets and subtle stereoelectronics features and structural complexity, have given rise to the industrial manufacture of a host of new enantiopure materials showing promise for asymmetric syntheses and combinatorial chemistry.It is the core of sustainable development of asymmetric catalysis to design and synthesize new chiral ligands. On the basic reorganization of their skeleton features and the related asymmetric reactions, we have found it was understood...