Development Of A Canine Adenovirus Type 1 Vaccine Strain E3-Deleted Based Expression Vector

Human adenoviruses are commonly used but have many significant disadvantages as vehicles for recombinant vaccine delivery and also for gene therapy. First, the majority of the population has been infected with human adenovirus and therefore underwent an immune response against the virus. Human adenoviral vector may be progressively eliminated due to a preexisting immune response to human adenovirus in the patients. Second, human adenoviral vector bearing the minimum of a packaging sequence and inverted terminal repeats creats the possibility of co-replication of a recombinant human adenoviral vector with a wild-type human adenovirus during a natural infection and this raises doubts concerning the safety of human adenoviral vector. Animal Adenovirus can infect and tranduce human cells. There might not be neutralizing antibodies against animal adenovirus in the majority of the population. So the use of animal adenovirus as gene transfer vector to circumvent some of the shortcomings of human adenoviral vectors should be a good alternative to human adenoviral vector. Anyway, animal adenovirus are still good candidates for the development of recombinant vaccines in their respective species. Already established animal...