Studies On The Changes Of Intermediate Filament-lamina-nuclear Matrix System And Its Relations With C-myc Oncogene Expression In Normal Erythroid And Induced Murine Erythroleukemia(MEL) Cell Differentiation

It has become a new field in the modern biology of studying the relationship of cell differentiation and regulation of gene expression with the intermediate filament-lamina-nuclear matrix( IF- L- NM) system, a recently found whole cell stereo- network system that generally existed in eukaryocytes, for maitainance of cellular morphology and function. To unravel the possible mechanism of the naturally occurring enucleation during terminal differentiation of mammalian erythrocytes and malignant regulation of tumor cells by EDF, we performed experiments in comparision of the diversity between erthroid cells with denucleation (mouse) and non-deneucleation(chicken) and in the study of changes of IF-L-NM system during cell differentiation, de-differentiation (cancerization) and re-differentiation (malignant reversion) by using chicken and mouse erythroid cells and murine erythroleukemia (MEL) cells as materials. In addition, we also carried out the study of the relationship between c-myc expression and the nuclear matrix in induced MEL cells in order to...