The Expression Of Multiple Drug Resistance Associated Genes In Ovarian Cancer

Purpose:Ovarian cancer is the most lethal gynecological carcinoma. Successful cytoreductive surgery followed by the administration of intensive platinum or Taxol based combination chemotherapeutic regimens is the standard treatment for the advanced cancer. One of the main reasons that limit the success of the treatment, however, is the emergence of drug resistance in the tumor cell population, which could be either intrinsic or acquired. It is believed that the development of resistance to antineoplastic drugs in which several genes involved is frequently associated with broad cross-resistance to even structurally dissimilar drugs. Furthermore, different type of tumor treated by different drugs manifested varied mechanism of resistance. The investigation of the expression of multiple drug resistance associated genes is helpful for selecting the proper regimen of chemotherapy, finding the method to avoid and reverse resistance, improving the efficiency of treatment and judging of prognosis.Methods and results:The study included the following 3 parts:1. The co-expression of multiple drug resistance associated genes in ovarian cancer tissue.The aim of the investigation was to find out the relationship between the expression of MDR1 (multidrug resistance gene), MRP (multidrug resistance protein), LRP (Lung resistance protein) and GST- π (Glutathione S-transferase pi) with the clinical pathological characteristics and the prognosis in the ovarian...